Duke researchers have identified that mutations in the isocitrate dehydrogenase (IDH) gene contribute to the formation of benign tumours in cartilage that can be a precursor to malignancies.  These benign tumours, known as enchondromas, are associated with severe pain, fractures, and skeletal deformities. They also have the potential to evolve into a cancerous form known as chondrosarcomas. Over 40% of primary bone cancers are chondrosarcomas, … Continue reading Researchers identify point of epigenetic methylation which drives cartilage tumour formation.