Tag Archives: app

Dysfunctional precursor protein impairs making of new neurons in brain.

APP as a gene regulator.  The intracellular domain of APP can translocate into the nucleus upon secretase cleavage and activate transcription of target genes.  Credit:  University of Zurich.

Amyloid precursor protein (APP) modulates the many processes through which newborn neurons are generated in the adult brain, state researchers from Baylor College of Medicine in a new study. An important component of the proper formation of these neurons are the GABAergic interneurons, which maintain a state of homeostasis between excitation and inhibition. When new neurons are generated from neural

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