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Study shows prenatal alcohol exposure alters development of brain function.

In the first study of its kind researchers from the Children’s Hospital Los Angeles found that children with fetal alcohol spectrum disorders (FASD) showed weaker brain activation during specific cognitive tasks than their unaffected counterparts.  These novel findings suggest a possible neural mechanism for the persistent attention problems seen in individuals with FASD. The results of this study will be published in Cerebral Cortex.

Functional magnetic resonance imaging (fMRI) has been used to observe brain activity during mental tasks in children with FASD, however, the team are the first to utilize these techniques to look at brain activation over time. The researchers wanted to see if the differences in brain activation between children with FASD and their healthy peers were static, or if they changed as children got older.

FASD encompasses the broad spectrum of symptoms that are linked to in utero alcohol exposure, including cognitive impairment, deficits in intelligence and attention and central nervous system abnormalities.  These symptoms can lead to attention problems and higher societal and economic burdens common in individuals with FASD.

During the period of childhood and adolescence, brain function, working memory and attention performance all rapidly improve, suggesting that this is a crucial time for developing brain networks. To study how prenatal alcohol exposure may alter this development, researchers observed a group of unaffected children and a group of children with FASD over two years. They used fMRI to observe brain activation through mental tasks such as visuo-spatial attention, how humans visually perceive the spatial relationships among objects in their environment, and working memory.

The group found that there were significant differences in development brain activation over time between the two groups, even though they did not differ in task performance.  While the healthy control group showed an increase in signal intensity over time, the children with FASD showed a decrease in brain activation during visuo-spatial attention, especially in the frontal, temporal and parietal brain regions.

These results demonstrate that prenatal alcohol exposure can change how brain signaling develops during childhood and adolescence, long after the damaging effects of alcohol exposure in utero. The atypical development of brain activation observed in children with FASD could explain the persistent problems in cognitive and behavioral function seen in this population as they mature.

Source:  Children’s Hospital Los Angeles

 

fMRI Scan of Working Memory Activation in Typically-Developing Children.  Credit:  Children’s Hospital Los Angeles
fMRI Scan of Working Memory Activation in Typically-Developing Children. Credit: Children’s Hospital Los Angeles

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