Skip to content

Study links sex hormone levels in the blood to risk of sudden cardiac arrest.

Measuring the levels of sex hormones in patients’ blood may identify patients likely to suffer a sudden cardiac arrest, a heart rhythm disorder that is fatal in 95 percent of patients.  A new study from the Cedars-Sinai Heart Institute shows that lower levels of testosterone, the predominant male sex hormone, were found in men who had a sudden cardiac arrest. Higher levels of estradiol, the major female sex hormone, were strongly associated with greater chances of having a sudden cardiac arrest in both men and women.

Because sudden cardiac arrest is usually fatal, the medical community are constantly looking for ways to predict which patients are susceptible so they can concentrate on prevention.  If doctors wait until someone has a sudden cardiac arrest, it is usually too late for treatment.

Unlike heart attacks (myocardial infarction), which are typically caused by clogged coronary arteries reducing blood flow to the heart muscle, sudden cardiac arrest is the result of defective electrical impulses. Patients may have little or no warning, and the disorder usually causes nearly instantaneous death. Every year, 250,000 to 300,000 people in the U.S. and up to 5 million worldwide die from sudden cardiac arrest.

Despite years of significant advances in emergency medicine and resuscitation, just 5 percent of those who suffer sudden cardiac arrest survive. For patients at known risk for this or other heart rhythm abnormalities, an implantable cardioverter-defibrillator, or ICD, may be placed in the chest or abdomen to detect faulty electrical impulses and provide a shock to return normal rhythm.

The sex hormone findings are a result of the Oregon Sudden Unexpected Death Study, a comprehensive, 16-hospital, multi-year assessment of cardiac deaths in the 1 million population Portland, Oregon metropolitan area. Led by Chugh and funded in part by the National Heart, Lung, and Blood Institute, the study’s goal is to shed light on the risk factors, triggers and genetic defects associated with sudden cardiac death.

Researchers measured blood hormone levels in 149 patients who had a sudden cardiac arrest, comparing them with levels in 149 patients who had coronary artery disease but did not have sudden cardiac arrest.

The study’s findings were as follow; men who had sudden cardiac arrests had testosterone levels of 4.4 nanograms per milliliter, compared to 5.4 nanograms per milliliter for men who did not have sudden cardiac arrest.  Men who had sudden cardiac arrest had estradiol levels of 68 picograms per milliliter, compared to 52 picograms per milliliter for men who did not have sudden cardiac arrest and women who had sudden cardiac arrest had estradiol levels of 54 picograms per milliliter, compared to 36 picograms per milliliter for the control group.

This is the first time it has been reported that there is an association between sex hormone levels and sudden cardiac arrest.  While these findings need to be confirmed by other studies, they suggest that higher testosterone levels in men may offer protection from sudden cardiac arrest and lower levels of estrogen may protect both men and women.

Source:  Cedars-Sinai

 

Study Links Sex Hormone Levels in the Blood to Risk of Sudden Cardiac Arrest - healthinnovations

 

Healthinnovations View All

Michelle Petersen is the founder of Healthinnovations, having worked in the health and science industry for over 21 years, which includes tenure within the NHS and Oxford University. Healthinnovations is a publication that has reported on, influenced, and researched current and future innovations in health for the past decade.

Michelle has been picked up as an expert writer for Informa publisher’s Clinical Trials community, as well as being listed as a blog source by the world’s leading medical journals, including the acclaimed Nature-Springer journal series.

Healthinnovations is currently indexed by the trusted Altmetric and PlumX metrics systems, respectively, as a blog source for published research globally. Healthinnovations is also featured in the world-renowned BioPortfolio, BioPortfolio.com, the life science, pharmaceutical and healthcare portal.

Most recently the Texas A&M University covered The Top 10 Healthinnovations series on their site with distinguished Professor Stephen Maren calling the inclusion of himself and his team on the list a reflection of “the hard work and dedication of my students and trainees”.

Michelle Petersen’s copy was used in the highly successful marketing campaign for the mega-hit film ‘Jumanji: The Next Level, starring Jack Black, Karen Gilian, Kevin Hart and Dwayne ‘The Rock’ Johnson. Michelle Petersen’s copywriting was part of the film’s coverage by the Republic TV network. Republic TV is the most-watched English language TV channel in India since its inception in 2017.

An avid campaigner in the fight against child sex abuse and trafficking, Michelle is a passionate humanist striving for a better quality of life for all humans by helping to provide traction for new technologies and techniques within healthcare.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.