Genetic information is stored in DNA, tiny strands of nucleic acid that contain instructions for the functioning of the human body. To express this genetic data, our DNA is copied into RNA molecules, which then translate the instructions into proteins that perform tasks in cells.
Several years ago, scientists discovered a new type of RNA molecule. Unlike all other known RNAs, this molecule is circular, and was labelled circular RNA. Although circRNA molecules are abundant, little has been known about how they are produced. Moreover, little has been known about the role they play in our biology, and next to nothing has been known about the role they play in disease.
Now, in an article published in the journal Molecular Cell researchers at the Hebrew University of Jerusalem and the Max Dellbruck Institute have discovered how circRNAs are produced.
The team found that circRNAs not only compete with normal RNAs, but the body actually produces them at the expense of normal RNA. Therefore, the mere fact of circRNAs’ production has an enormous impact on how human genes are expressed, which affects how the body develops and functions.
The researchers also demonstrated that circular RNA molecules are highly produced in the brain, and in many cases from genes with very important functions. This strongly suggests that circRNAs play an important role in brain function, and likely in brain disease.
In addition, the researchers identified the protein ‘muscleblind’ as a factor involved in circRNA biogenesis, and showed that muscleblind can enhance and regulate the production of a subset of circular RNAs.
Importantly, defects in muscleblind function are known to cause a severe degenerative disease called myotonic dystrophy. Characterized by progressive muscle wasting and weakness, this is the most common form of muscular dystrophy that begins in adulthood. When considered together, the important role played by muscleblind in regulating circRNAs, combined with these molecules’ abundance in the brain, suggests that circRNAs might be involved in development of myotonic dystrophy.
This research is significant from several perspectives. By mapping how circRNAs are produced, it helps advance the medical community’s understanding of general molecular biology. In addition, it might be strongly relevant for understanding and eventually treating degenerative diseases both in muscle and the brain.
Michelle Petersen is the founder of Healthinnovations, having worked in the health and science industry for over 21 years, which includes tenure within the NHS and Oxford University. Healthinnovations is a publication that has reported on, influenced, and researched current and future innovations in health for the past decade.
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Michelle Petersen’s copy was used in the highly successful marketing campaign for the mega-hit film ‘Jumanji: The Next Level, starring Jack Black, Karen Gilian, Kevin Hart and Dwayne ‘The Rock’ Johnson. Michelle Petersen’s copywriting was part of the film’s coverage by the Republic TV network. Republic TV is the most-watched English language TV channel in India since its inception in 2017.
An avid campaigner in the fight against child sex abuse and trafficking, Michelle is a passionate humanist striving for a better quality of life for all humans by helping to provide traction for new technologies and techniques within healthcare.