Neurorehabilitation helps hemaparetic stroke patients confronted with loss of motor skills on one side of their body, to recover some of their motor functions after a cerebrovascular accident. One of the most promising tracks in neuro-rehabilitation consists in amplifying the motor learning ability after a stroke, in other words how to learn (again) how to make movements with the parts of the human body impacted after a stroke.
Pilot studies have shown at this matter that tDCS (transcranial direct current stimulation), a non-invasive and painless cerebral stimulation method, allowed to modulate the cerebral activity and to increase the motor performances of patients who have suffered a stroke.
This method consists of applying low voltage electric currents on the patient’s head by means of electrodes during short periods of time. In 2012, a study conducted by researchers from the Université catholique de Louvain (UCL) demonstrated that tDCS amplified the motor learning and the long-term motor memory of the patient after a stroke. This study was then validated via the use of functional Magnetic Resonance Imaging (fMRI) of the brain. The current study is published in the journal Brain.
Nineteen hemiparetic stroke patients (with a motor deficit in the upper limb) participated to this new clinical trial. In order to avoid study bias, the stimulations were performed in a double-blind, randomised fashion. Each patient received a real stimulation as well as a placebo-stimulation during two separate sessions. Because the tDCS was as good as completely imperceptible, it became impossible for patients to determine if they received a true or a placebo-stimulation.
During the first stimulation session (real or placebo), the patients learned how to perform a task with a paralysed hand, combining speed and accuracy. One week later, they performed the learned task while the functional MRI scanner recorded their cerebral activity. After one week, this experience was completely done over again with the other stimulation (placebo or real).
As in the previous study, the non-invasive cerebral stimulation amplified the motor learning capacity with the paralyzed hand and the long-term memory retention in a spectacular way for patients with a chronic stroke.
Functional MRI was also used to demonstrate that the combination of motor learning and non-invasive cerebral stimulation improves the efficiency of the cerebral activity. One week after the placebo stimulation, the cerebral activations measured via the functional MRI were very diffuse.
In the placebo group large cerebral zones were somehow ‘recruited’ although motor performance was low with a poor retention. On contrast, one week after real stimulation, the cerebral activation was focussed on the essential motor zones, almost identical to a person without stroke-impact although the motor performance was significantly better, giving an enhanced task retention. In other words, the combination of motor learning and tDCS reinforced the essential motor zones and this specific network was reactivated one week after the real intervention.
For thousands of stroke victims, this study opens considerable perspectives in the domain of neurorehabilitation. A better understanding of the cerebral functioning after a stroke and how non-invasive cerebral stimulation works will help researchers to develop the neurorehabilitation of the future.
The results of this study will be implemented within the consortium Louvain Bionics to develop future robotics, bionics, cybernetics and neuroprosthesis.
Source: Université catholique de Louvain
Michelle is a health industry veteran who taught and worked in the field before training as a science journalist.
Featured by numerous prestigious brands and publishers, she specializes in clinical trial innovation--expertise she gained while working in multiple positions within the private sector, the NHS, and Oxford University.