Neurobiologists at NYU Langone, University of Pennsylvania, University of Lyon and Linkoping University have found a surprising and paradoxical effect of abuse-related cues in rat pups, those cues also can lower depressive-like behaviour when the rat pups are fully grown. These paradoxical properties may help shed light on why certain cues such as pictures or odours associated with early life abuse can sometimes reduce stress in those same individuals as adults.
In experiments conducted in infant and adult rats, the team found that trauma and pain experienced in infancy clearly led to higher rates of adult rat depression-like behaviour. However, in an ironic twist, presenting odour cues associated with the early life trauma during depressive episodes in the same rats, now fully grown, lowered depression-like behaviour. Results also showed that the adult rats’ brain biology had been altered by the trauma linked cues, much like what happens in the human brain on antidepressant drugs involving serotonin. The study is published in the Proceedings of the National Academy of Sciences (PNAS).
The team state that these results are surprising because cues associated with trauma experienced as adults provoke fear and do not rescue depressive behaviour. Previous work by the team showed that the infant brain has limited ability to link trauma to fear areas in the brain, such as the amygdala, and instead, activate areas of the brain important in approach and attachment. Once these cues are linked to the attachment circuitry in the brain, they remain capable of activating the attachment circuit throughout the lifespan.
The team’s results show important details about the biological effect of infant trauma in mammals, and reveals how the brain may react to such trauma among humans, as well.
A key finding of the study is the trauma-related paradoxical, and opposite, effect of serotonin in infancy and adulthood. The trauma experienced by the infant rats increased serotonin, and the study showed that giving rat pups antidepressant drugs, such as selective serotonin reuptake inhibitors (SSRI) was sufficient to mimic the effects of trauma and produced depression in these rats during later life.
It’s possible that giving SSRI medications to children could be detrimental to mental health in adulthood. The researchers believe that their research offers the first evidence for the impact of serotonin pathways. The infant trauma increases serotonin to produce brain programming of later life depression and the infant trauma cue increases serotonin to alleviate the adult depressive-like symptoms.
Later tests on the same rats when they matured showed that the infant trauma linked cues continued to trigger a similar serotonin response. However in adults the production of more serotonin helped to alleviate the depression, similar to SSRIs. The odour cues’ effects, researchers showed, altered overall gene activity in the amygdala region of the brain, which is responsible for processing emotions, such as fear and pleasure. The adult rats experienced the same mood-uplifting effects from increased serotonin as other rats did when researchers blocked stress pathways in the brain and just added serotonin.
The team now plan to use the same rat model system to better understand other aberrant behaviors and investigate whether changes in serotonin, or other neurotransmitters, can similarly influence adult behaviour.
Source: NYU Langone Medical Center
Michelle Petersen is the founder of Healthinnovations, having worked in the health and science industry for over 21 years, which includes tenure within the NHS and Oxford University. Healthinnovations is a publication that has reported on, influenced, and researched current and future innovations in health for the past decade.
Michelle has been picked up as an expert writer for Informa publisher’s Clinical Trials community, as well as being listed as a blog source by the world’s leading medical journals, including the acclaimed Nature-Springer journal series.
Healthinnovations is currently indexed by the trusted Altmetric and PlumX metrics systems, respectively, as a blog source for published research globally. Healthinnovations is also featured in the world-renowned BioPortfolio, BioPortfolio.com, the life science, pharmaceutical and healthcare portal.
Most recently the Texas A&M University covered The Top 10 Healthinnovations series on their site with distinguished Professor Stephen Maren calling the inclusion of himself and his team on the list a reflection of “the hard work and dedication of my students and trainees”.
Michelle Petersen’s copy was used in the highly successful marketing campaign for the mega-hit film ‘Jumanji: The Next Level, starring Jack Black, Karen Gilian, Kevin Hart and Dwayne ‘The Rock’ Johnson. Michelle Petersen’s copywriting was part of the film’s coverage by the Republic TV network. Republic TV is the most-watched English language TV channel in India since its inception in 2017.
An avid campaigner in the fight against child sex abuse and trafficking, Michelle is a passionate humanist striving for a better quality of life for all humans by helping to provide traction for new technologies and techniques within healthcare.