New ‘whole-brain’ imaging technique isolates autistic and non-autistic brain differences for first time.


The functional differences between autistic and non-autistic brains have been isolated for the first time, following the development of a new methodology for analysing MRI scans.  Developed by researchers at the University of Warwick, the methodology, called Brain-Wide Association Analysis (BWAS), is the first capable of creating panoramic views of the whole brain and provides scientists with an accurate 3D model to study.

The New big data methodology can analyse over 1 billion pieces of data. The methodology can potentially isolate the areas of the brain involved with other cognitive problems, including Obsessive Compulsive Disorder, ADHD and schizophrenia.  The opensource study is published in the journal Brain.

The researchers used BWAS to identify regions of the brain that may make a major contribution to the symptoms of autism.  BWAS does so by analysing 1,134,570,430 individual pieces of data; covering the 47,636 different areas of the brain, called voxels, which comprise a functional MRI (fMRI) scan and the connections between them.  Previous methodologies which processed this level of data were restricted to modelling only limited areas.

In the current study the ability to analyse the entire data set from an fMRI scan provided the researchers the opportunity to compile, compare and contrast accurate computer models for both autistic and non-autistic brains.  The researchers collected the data from hundreds of fMRI scans of autistic and non-autistic brains.  By comparing the two subsequent models the researchers isolated twenty examples of difference, where the connections between voxels of the autistic brain were stronger or weaker than the non-autistic .

The team identified differences which included key systems involved with brain functions relating to autism.  They identified a key system in the temporal lobe visual cortex with reduced cortical functional connectivity. This region is involved with the face expression processing involved in social behaviour. This key system has reduced functional connectivity with the ventromedial prefrontal cortex, which is implicated in emotion and social communication.

The current study also identified a second key system relating to reduced cortical functional connectivity, a part of the parietal lobe implicated in spatial functions.

The researchers propose that these two types of functionality, face expression-related, and of one’s self and the environment, are important components of the computations involved in theory of mind, whether of oneself or of others, and that reduced connectivity within and between these regions may make a major contribution to the symptoms of autism.

By using meta-analysis and a rigorous statistics approach the researchers were able to collect and use a big data set to obtain significant results, the likes of which have not been seen in autistic literature before.  The group used BWAS to analyse resting state fMRI data collected from 523 autistic people and 452 controls. The amount of data analysed helped to achieve the sufficient statistical power necessary for this first voxel-based, comparison of whole autistic and non-autistic brains. Until the development of BWAS this had not been possible.

The team surmise that BWAS tests for differences between patients and controls in the connectivity of every pair of voxels at a whole brain level. Unlike previous seed-based or independent components-based approaches, this method has the great advantage of being fully unbiased in that the connectivity of all brain voxels can be compared, not just selected brain regions.

The team states that the methodology can potentially isolate the areas of the brain involved with other cognitive problems, including Obsessive Compulsive Disorder, ADHD and schizophrenia.

Source:  University of Warwick

The pattern of altered functional connectivity. (A) The functional connectivity matrix calculated from the blood oxygenation level-dependent signals in the significant voxels in each of the 20 regions of interest based on the 20 AAL regions that contained ≥20 significant voxels. Probability values are shown in the chart as red if they are significantly stronger in the autistic group, and blue if they are significantly weaker in the autistic group, after Bonferroni correction (see colour bar for P-values). (B) A schematic diagram showing the voxel region of interest-based connectivity differences between the autistic and the control group. The glass brains were generated using BrainNet Viewer (http://www.nitrc.org/projects/bnv/). CAU = caudate; CUN = cuneus; PCL = paracentral lobule; PCUN = precuneus; PreCG = precentral gyrus; SFGdor = superior frontal gyrus; SMA = supplementary motor area.  Autism: reduced connectivity between cortical areas involved in face expression, theory of mind, and the sense of self.  Feng et al 2015.

The pattern of altered functional connectivity. (A) The functional connectivity matrix calculated from the blood oxygenation level-dependent signals in the significant voxels in each of the 20 regions of interest based on the 20 AAL regions that contained ≥20 significant voxels. Probability values are shown in the chart as red if they are significantly stronger in the autistic group, and blue if they are significantly weaker in the autistic group, after Bonferroni correction (see colour bar for P-values). (B) A schematic diagram showing the voxel region of interest-based connectivity differences between the autistic and the control group. The glass brains were generated using BrainNet Viewer (http://www.nitrc.org/projects/bnv/). CAU = caudate; CUN = cuneus; PCL = paracentral lobule; PCUN = precuneus; PreCG = precentral gyrus; SFGdor = superior frontal gyrus; SMA = supplementary motor area. Autism: reduced connectivity between cortical areas involved in face expression, theory of mind, and the sense of self. Feng et al 2015.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s