Degeneration of the white matter of the brain may be an early marker of specific types of Alzheimer’s disease (AD), including early-onset AD, according to results of a new study from researchers at the San Raffaele Scientific Institute. The study is published in the journal Neurology.
The team state that Alzheimer’s is a gray matter disease, however, white matter damage has a central role in how the disease strikes and progresses. They go on to add that Alzheimer’s disease is an irreversible, progressive brain disease that slowly destroys memory and thinking skills. The disease is characterized by abnormal deposits of proteins that form amyloid plaques and tau tangles throughout the brain and a loss of neurons that causes brain tissue to shrink over time. Where or how the disease begins is not completely understood.
In the current study the researchers used diffusion tensor imaging (DTI) to assess the white matter tracts in 53 patients with three types of AD, namely, early-onset AD and two atypical types of AD called focal syndromes because they affect localized parts of the brain.
The team explain that unlike late-onset AD that occurs after age 65 and is characterized primarily by progressive memory loss, patients with early-onset AD have impairment in several regions of the brain, including deficits in executive functioning and visuospatial abilities. Focal AD syndromes may cause visual disturbances or language deficits.
DTI, a specialized magnetic resonance imaging technique that uses the movement of water molecules to characterize the microstructure of biological tissues, is highly sensitive to white matter degeneration, state the team. They go on to add that their goal was to use DTI to identify similarities and differences in white tract damage across the AD spectrum and in relation to patterns of cortical atrophy.
The researchers’ analysis of the images revealed that all of the patients had extensive white matter damage, and showed regional gray matter damage. The white matter damage in patients with focal AD syndromes was much more severe and widespread than expected and cannot be explained solely by gray matter atrophy which was more localized.
The data findings support the theory that AD pathology may travel along white matter fibers from one region of the brain to another. The team hypothesize that in early-onset AD and atypical AD forms, white matter degeneration may be an early marker that precedes gray matter atrophy. DTI has the potential to assess the extensive disorganization of brain networks in focal AD even before overt cognitive deficits become apparent.
The team surmise that the results of the current study also underline the importance of identifying and diagnosing patients with early onset and focal AD syndromes. They conclude that because there is not much structural damage in the early stages of focal Alzheimer’s disease, there is a risk that patients may be misdiagnosed and excluded from clinical trials which could now be rectified by these newly discovered imaging markers.