The human nervous system is made up of an astonishing diversity of neurons. And yet only a very small number of proteins are needed to generate and determine the identity … Continue Reading Researchers identify a previously unknown regulatory mechanism of neurogenesis.
An important mystery has been why some cells in the body already have mutations seen in cancer, yet do not fully behave like the cancer. Now, researchers led by the … Continue Reading In a world’s first, researchers image the origins of cancer from the first affected cell.
Due in part to improvements in screening, the rates of new colorectal cancer diagnoses have been falling in the United States for people ages 50 and older. However, for people … Continue Reading Study identifies different genetic drivers of colorectal cancer in older and younger patients.
The recent surge in obesity prevalence has been greatly influenced by food intake and diet composition. Energy from food comes in three macronutrient forms- fat, protein, and carbohydrate. Over the … Continue Reading First liver-generated hormone to work with brain to control sugar-intake identified.
In humans, up to half of body mass is made up of skeletal muscle, which plays a key role in locomotion, posture, and breathing. Although skeletal muscles can overcome minor … Continue Reading Biologic-free mechanically induced muscle regeneration successful in animal studies.
Over the past century, the most reliable method of diagnosing diseases has been the microscopic visualization of thinly sectioned tissues mounted on glass slides. This practice of histopathology is universally … Continue Reading Pen-sized microscope which identifies cancer cells in the operating room, out of animal studies.
Learning and memory are among the brain’s most fundamental tools for survival. Accurate encoding of ‘contextual’ memories, which are associated with particular experiences, enables the person to exhibit the appropriate … Continue Reading Elusive ‘switch’ which helps brain distinguish safety from danger identified.
Age is the largest risk factor for numerous pathologies, ranging from neurodegeneration to cancer. These pathologies likely arise from a loss of tissue homeostasis driven by one or more basic … Continue Reading New role for mitochondria identified in cellular senescence and aging.
Major depressive disorder is a highly familial illness and the leading cause of disability worldwide for persons 15 to 44 years of age. It is associated with increased mortality resulting … Continue Reading Study shows that both genetics and environment impact depression.
More than 40,000 babies in the United States, or about 1 in 100 births, are born annually with a congenital heart defect. Congenital heart defect, is a problem in the … Continue Reading Researchers identify natural triggers to ‘override’ congenital heart defect in newborns.
Alzheimer’s disease poses a health problem of pandemic proportions. It is estimated that by the year 2030 there will be greater than 60 million people worldwide with AD, and $375 … Continue Reading Newly identified role for ApoE explains its effects in Alzheimer’s.
Heart muscle is activated by ionized calcium, with the signaling pathway utilising allosteric mechanisms in the thin filament. Knowledge about the structure-function relationship among proteins in this filament is critical … Continue Reading Previously unknown protein critical to heart muscle contraction identified.
Signs of autism, schizophrenia and bipolar disorder often take years to manifest. Studying suspect disease genes in the brain early in life could prove valuable in the development of new … Continue Reading Study maps autism-linked protein in neurodevelopment.
Melanoma incidence has been rapidly increasing worldwide, with fewer than 10% of people whose melanoma tumours have spread or metastasized surviving longer than a decade after detection. Despite the considerable … Continue Reading New ctDNA blood-test for melanoma beats standardised test in human trials.
The motivation for natural rewards such as food, sex and exercise, and also of drugs such as nicotine, relies on neurons in the brain’s reward system, based in a brain … Continue Reading Molecular ‘switch’ reduces nicotine’s effect on the brain in animal model.
Semen quality is a measure of the ability of semen to accomplish fertilization and a measure of fertility in a man. It is the sperm in the semen that are … Continue Reading ‘Spermbots’ successful in proof-of-concept fertility studies.