Viral infections leave a signature – healthinnovations
Network analysis of the 127-gene Influenza signature using Ingenuity Pathway Analysis. Of the 127 identified genes, 71 are involved in innate virus sensing and initiation of antiviral response pathways. Yellow boxes indicate transcription factors (STAT1, IRF7), RIG-1-like receptors (RLRs), 2’-5’-oligoadenylate synthetases and Interferon-induced proteins that have been previously implicated in response to influenza infection. Integrated, Multi-cohort Analysis Identifies Conserved Transcriptional Signatures across Multiple Respiratory Viruses. Khatri et al 2015.