It has long been known that transcriptional regulation during embryonic development relies on the regulation of thousands of genes. Within a particular cell type defined sets of DNA-binding transcription factors … Continue Reading Researchers map how transcription factors interact to create a heart.
It is known that the hippocampus is central to episodic memory and spatial navigation both of which rely on sequences of spatiotemporal information. Spatiotemporal trajectories are coded by theta sequences, … Continue Reading Study identifies previously unknown function in the brain involving memory.
It is known that chronic inflammation in the gut increases the risk of colon cancer by as much as 500%. Therefore, the genetic basis and mechanism of cancer proliferation in … Continue Reading Researchers show how gut inflammation initiates colon cancer.
With more than 25% of high school seniors reporting recent use and 6.5% of 12th graders being daily users, marijuana (MJ) is the most frequently used illicit substance among adolescents. … Continue Reading Neuroimaging shows that young starting age of marijuana causes arrested neurodevelopment.
Synthetic biology uses natural molecules and assembles them into a system that acts unnaturally. The ability to control the transfer of molecules through cellular membranes is an important function in … Continue Reading New ‘nanoneedles’ puncture cell membrane to release payload on command.
With Alzheimer’s disease medical professionals have to conduct costly brain imaging scans, and sometimes, invasive cerebral spinal fluid tests to rule out other diseases. Now, a new study from researchers … Continue Reading Human study identifies biomarker in blood for Alzheimer’s disease.
The MERS coronavirus (MERS-CoV) was first isolated from the sputum of a patient who died of respiratory and renal failure in Saudi Arabia in 2012. Since then, more than three-quarters … Continue Reading First-ever autopsy of patient with MERS provides unprecedented clinical insights.
The immune system exercises constant vigilance to protect the body from external threats, including what the person eats and drinks. A careful balancing act plays out as digested food travels … Continue Reading Study finds neurons in gut regulate the immune system to control inflammation.
The liver plays a critical role in how the body metabolizes drugs and produces key proteins. This is why liver models are increasingly being developed in the lab as platforms … Continue Reading Researchers successfully 3D-print biomimetic liver tissue for drug screening.
Type 2 diabetes is a chronic illness characterised by the presence of elevated blood glucose levels. It accounts for between 80 and 90% of diabetes cases and is one of … Continue Reading Large-scale study identifies an epigenetic marker for Type 2 diabetes.
Scientists have long speculated that schizophrenia, which affects about 1 in every 100 adults worldwide, originates in part in the hippocampus, the brain’s headquarters for memory and spatial navigation. As … Continue Reading Schizophrenia linked to loss of cells in brain’s memory centre for the first time.
Preeclampsia, which affects 5 to 8% of pregnancies worldwide, is characterized by high blood pressure and protein in the urine. The disorder is the number one reason physicians decide to … Continue Reading New field-based test for preeclampsia validated in large-scale study.
The incidence of HIV-associated dementia has declined dramatically since the introduction of potent combined antiretroviral therapy; however, milder forms of HIV-associated neurocognitive disorders (HAND) persist. Some 30 to 50 % of … Continue Reading Study shows how neural networks adapt to the presence of a toxic HIV protein.
Pre-term birth is a birth which takes place before 37 weeks of pregnancy. According to the Centers for Disease Control and Prevention, in 2014, preterm birth affected one out of … Continue Reading Large-scale study successfully validates test for preterm birth risk.
The auditory nerve is comprised of thousands of tiny nerve fibers responsible for transmitting sound to and from the ear and the brain. Recent discoveries have shown that they are … Continue Reading Researchers identify previously unknown compensatory brain amplifier for hear loss.
The mammalian Y chromosome encodes a specialized set of genes that are essential for male viability and fertility. In particular, the sex-determining region Y (SRY) protein is necessary to initiate … Continue Reading Male mice without any Y chromosome produce offspring with assisted reproduction.