Posted July 5, 2016 by Healthinnovations bone health

First ever bone-derived hormone to affect exercise capacity identified.

During exercise, muscle function needs to significantly increase; this requires that the uptake and breakdown of the two main nutrients of myofibers, glucose and fatty acids (FAs), markedly rise. The ability of bone to sense mechanical forces, the physical proximity of the two tissues, and the fact that exercise capacity and bone mass decline at the same time has long suggested that a crosstalk between bone and muscle may exist. Now, a study from researchers at the Columbia University Medical Center shows that when a person exercises, their bones produce a hormone called osteocalcin that increases muscle performance. The team states that their study describes the first bone-derived hormone known to affect exercise capacity and shows that osteocalcin injections can reverse the age-related exercise capacity decline in mice. The opensource study is published in the journal Cell Metabolism.

Previous studies show that osteocalcin naturally declines in humans as they age, beginning in women at age 30 and in men at age 50. Osteocalcin favours physiological functions that, like memory and male fertility, greatly decline with age.

This observation raises the possibility that osteocalcin may regulate other physiological processes severely affected by aging, such as muscle function during exercise. The current study uncovers a bone-to-muscle feedforward endocrine axis that favours adaptation to exercise and can reverse the age-induced decline in exercise capacity.

The current study utilised mice genetically engineered so osteocalcin couldn’t signal properly in their muscles to investigate whether this hormone’s levels were affecting exercise performance. To determine the cellular mechanisms behind osteocalcin’s effects, the group measured levels of glycogen, glucose, and acylcarnitines in mice, with and without osteocalcin. The researchers found that the hormone helps muscle fibers uptake and metabolize glucose and fatty acids as nutrients during exercise. Results show that without osteocalcin muscle signaling, the mice ran 20%-30% less time and distance than their healthy counterparts before reaching exhaustion. Data findings show that during exercise in mice and humans, the levels of osteocalcin in the blood increase depending on how old the organism is.

Results show that in 3-month-old adult mice, osteocalcin levels spiked approximately four times the amount that the levels in 12-month-old mice did when the rodents ran for 40 minutes on a treadmill. Data findings show that the 3-month-old mice could run for about 1,200 meters before becoming exhausted, while the 12-month-old mice could only run half of that distance.

The lab state that when healthy mice that were 12 and 15 months old, whose osteocalcin levels had naturally decreased with age, were injected with osteocalcin, their running performance matched that of the healthy 3-month-old mice. They go on to add that the older mice were able to run about 1,200 meters before becoming exhausted; it was extremely surprising that a single injection of osteocalcin in a 12-month-old mouse could completely restore its muscle function to that of a 3-month-old mouse. They conclude that, to their knowledge, it had never been shown before that bone actually influences muscle in any way.

The team surmise that they have shown that bones are making a hormone called osteocalcin that provides an explanation for why humans can exercise and that this hormone is powerful enough to reconstitute, in older animals, the muscle function of young animals. For the future, the researchers state that osteocalcin is the only hormone responsible for adaptation to exercise in mice and humans, and it is the only known bone-derived hormone that increases exercise capacity; therefore, this may be one way to treat age-related decline in muscle function in humans.

Source: Columbia University Medical Center

Stem cells self-organize to form a hollow ball of cells. Credit: In Kyoung Mah, Francesca Mariani.

Healthinnovations View All

Michelle Petersen is the founder of Healthinnovations, having worked in the health and science industry for over 21 years, which includes tenure within the NHS and Oxford University. Healthinnovations is a publication that has reported on, influenced, and researched current and future innovations in health for the past decade.

Michelle has been picked up as an expert writer for Informa publisher’s Clinical Trials community, as well as being listed as a blog source by the world’s leading medical journals, including the acclaimed Nature-Springer journal series.

Healthinnovations is currently indexed by the trusted Altmetric and PlumX metrics systems, respectively, as a blog source for published research globally. Healthinnovations is also featured in the world-renowned BioPortfolio, BioPortfolio.com, the life science, pharmaceutical and healthcare portal.

Most recently the Texas A&M University covered The Top 10 Healthinnovations series on their site with distinguished Professor Stephen Maren calling the inclusion of himself and his team on the list a reflection of “the hard work and dedication of my students and trainees”.

Michelle Petersen’s copy was used in the highly successful marketing campaign for the mega-hit film ‘Jumanji: The Next Level, starring Jack Black, Karen Gilian, Kevin Hart and Dwayne ‘The Rock’ Johnson. Michelle Petersen’s copywriting was part of the film’s coverage by the Republic TV network. Republic TV is the most-watched English language TV channel in India since its inception in 2017.

An avid campaigner in the fight against child sex abuse and trafficking, Michelle is a passionate humanist striving for a better quality of life for all humans by helping to provide traction for new technologies and techniques within healthcare.