The lab state that when healthy mice that were 12 and 15 months old, whose osteocalcin levels had naturally decreased with age, were injected with osteocalcin, their running performance matched that of the healthy 3-month-old mice. They go on to add that the older mice were able to run about 1,200 meters before becoming exhausted; it was extremely surprising that a single injection of osteocalcin in a 12-month-old mouse could completely restore its muscle function to that of a 3-month-old mouse. They conclude that, to their knowledge, it had never been shown before that bone actually influences muscle in any way.
The team surmise that they have shown that bones are making a hormone called osteocalcin that provides an explanation for why humans can exercise and that this hormone is powerful enough to reconstitute, in older animals, the muscle function of young animals. For the future, the researchers state that osteocalcin is the only hormone responsible for adaptation to exercise in mice and humans, and it is the only known bone-derived hormone that increases exercise capacity; therefore, this may be one way to treat age-related decline in muscle function in humans.
Michelle Petersen is the founder of Healthinnovations, having worked in the health and science industry for over 21 years, which includes tenure within the NHS and Oxford University. Healthinnovations is a publication that has reported on, influenced, and researched current and future innovations in health for the past decade.
Michelle has been picked up as an expert writer for Informa publisher’s Clinical Trials community, as well as being listed as a blog source by the world’s leading medical journals, including the acclaimed Nature-Springer journal series.
Healthinnovations is currently indexed by the trusted Altmetric and PlumX metrics systems, respectively, as a blog source for published research globally. Healthinnovations is also featured in the world-renowned BioPortfolio, BioPortfolio.com, the life science, pharmaceutical and healthcare portal.
Most recently the Texas A&M University covered The Top 10 Healthinnovations series on their site with distinguished Professor Stephen Maren calling the inclusion of himself and his team on the list a reflection of “the hard work and dedication of my students and trainees”.
Michelle Petersen’s copy was used in the highly successful marketing campaign for the mega-hit film ‘Jumanji: The Next Level, starring Jack Black, Karen Gilian, Kevin Hart and Dwayne ‘The Rock’ Johnson. Michelle Petersen’s copywriting was part of the film’s coverage by the Republic TV network. Republic TV is the most-watched English language TV channel in India since its inception in 2017.
An avid campaigner in the fight against child sex abuse and trafficking, Michelle is a passionate humanist striving for a better quality of life for all humans by helping to provide traction for new technologies and techniques within healthcare.