A significant milestone in the evolution of the mammalian brain is the emergence of the corpus callosum, which is exclusively present in placental mammals. This commissure forms the largest axon tract in the human brain and is required for the integration of sensory, motor, and associative processes between the two cerebral hemispheres.
The lab observed that astrocytes are initially located beneath the area filled with fibroblasts, however, during fetal development a molecular pathway signals the astroglia to migrate forward and mature, allowing them to weave together into a thick column along the center of the brain, which pushes back against the gap and causes it to shrink. Results show that this column of astroglia acts as a bridge for callosal axons and allows them to cross between the two sides of the brain. Data findings show that as this bridge grows, the gap between the hemispheres shrinks until only a small portion of it remains, and the corpus callosum begins to form.
The group state that when there was an issue with molecular signaling, the astroglial cells didn’t change into multipolar cells, which prevents the formation of the callosal tract and resulted in callosal agenesis. The researchers explain that this midline area is one of the first places in the brain that exhibit these astroglial cell changes, and if these cells don’t make this transition, the remodeling process to form the corpus callosum doesn’t get started. They conclude that they’ve finally discovered one of the major causes for this group of disorders.
The team surmise that their findings show how astroglia remodel the telencephalic interhemispheric fissure during mouse and human development. They go on to add that further evidence demonstrates that defects in interhemispheric remodeling underlie callosal agenesis in mice and humans. For the future, the researchers state they now plan to use this knowledge to help make better diagnostic tests for callosal agenesis.
astrocytes, astroglia, callosal agenesis, genetics, healthinnovations, inflammation, microglia, neuroanatomy, neurobiology, neurodevelopment, neurogenetics, neuroimaging, neuroinflammation, neuroinnovations, opensource
Michelle Petersen is the founder of Healthinnovations, having worked in the health and science industry for over 21 years, which includes tenure within the NHS and Oxford University. Healthinnovations is a publication that has reported on, influenced, and researched current and future innovations in health for the past decade.
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An avid campaigner in the fight against child sex abuse and trafficking, Michelle is a passionate humanist striving for a better quality of life for all humans by helping to provide traction for new technologies and techniques within healthcare.