Brown or good fat has long been investigated as a treatment for obesity and Type 2 diabetes due to the fact it burns energy faster than white fat, a type of adipose tissue shown to lead to weight gain. Now, a study from researchers at Zurich University increases the amount of metabolism-boosting brown adipose tissue by employing two somatosensory neuron surface receptors as potential therapeutic targets. The team states their findings have implications for the treatment of obesity, diabetes, and other related metabolic disorders. The study is published in The FASEB Journal.
Previous studies show transient receptor potential channels (TRP channels) are a group of ion channels serving a variety of functions in the peripheral and central nervous systems. These channels mediate multiple sensations such as pain, warmth, pressure, or coldness, as well as different kinds of tastes, and vision. The TRPM8 protein is expressed in sensory neurons, and it is activated by cold temperatures and cooling agents, such as menthol. TRPP3 (TRP polycystic (P)3) is part of a family of TRP channels implicated in polycystic kidney disease when mutated. The current study shows the potential of TRPM8 and TRPP3 as targets involved in the formation of human brown fat.
The current study induces human bone marrow stem cells and subcutaneous belly fat cells to become white or brown fat, and also utilizes undifferentiated cells as a control. All 27 TRP channels were analyzed during the process. Results show some TRPs are not expressed, while other TRP channels are constantly present, or are only expressed during brown fat cell differentiation. Data findings show TRPM8 and TRPP3 were present at high levels in differentiated brown fat, but not in the progenitor cells.
The group also investigated the role of TRPM8 using specific activators or inhibitors and found stimulating TRPM8 strongly supports the browning of fat, whereas the presence of inhibitors impedes it. The function of TRPP3 was tested by using genetic manipulation to shows its ablation prevents the formation of brown fat. The researchers stress the ablation of TRPP3 did not prevent the formation of white fat.
The team surmises their study shows bothTRPM8 and TRPP3 sensory receptors are associated with the creation of brown fat in humans and may be activated by certain foods. For the future, the researchers state in the face of a growing number of diabetic and obese people, their work will hopefully contribute to the development of non-adrenergic stimulators of brown fat and the appreciation of functional food to influence brown fat formation.
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