Microglia filmed shaping synapses for the first time.

It is now that around one in ten cells in the human brain are microglia, which act as the first and main contact in the central nervous system’s active immune defense and guide healthy brain development. Researchers have proposed that microglia pluck off and eat synapses, connections between brain cells, as an essential step in the pruning of connections during early circuit refinement.  However, until now, no one had seen them do it.  Now, a study from researchers at EMBL captures microglia ‘nibbling’ on brain synapses. The team state their findings show that the special glial cells help synapses grow and rearrange, demonstrating the essential role of microglia in brain development.  The opensource study is published in the journal Nature Communications.

Previous studies show that microglia are highly motile glial cells which are proposed to mediate synaptic pruning during neuronal circuit formation. Disruption of signaling between microglia and neurons leads to an excess of immature synaptic connections, thought to be the result of impaired phagocytosis of synapses by microglia. However, until now the direct phagocytosis of synapses by microglia has not been reported and fundamental questions remain about the precise synaptic structures and phagocytic mechanisms involved.  The current study shows hat microglia directly engulf and eliminate synaptic material via trogocytosis, or ‘nibbling’, of synaptic structures.

The current study combines electron microscopy and light sheet fluorescence microscopy to make the first movie of microglia eating synapses.  Results show that around half of the time that microglia contact a synapse, the synapse head sends out thin projections, known as filopodia, to greet them. In one case the group witnessed fifteen synapse heads extended filopodia toward a single microglia as it picked on a synapse, meaning that microglia actually induce their growth most of the time.

The lab state that microglia might underly the formation of double synapses, where the terminal end of a neuron releases neurotransmitters onto two neighboring partners instead of one. They go on to add that this process can support effective connectivity between neurons and shows that microglia are broadly involved in structural plasticity; and might induce the rearrangement of synapses, a mechanism underlying learning and memory.

The team surmise that their findings allow them to propose a mechanism for the role of microglia in the remodeling and evolution of brain circuits during development.  For the  future, the researcher plan to investigate the role of microglia in brain development during adolescence and the possible link to the onset of schizophrenia and depression.

Source: European Molecular Biology Laboratory (EMBL)


microgia neuroinnovations twitter

One comment

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.