Stem cell treatment has been described as a regenerative medical technique used to treat or prevent a disease or condition, however, it is not possible to transplant the exact amount of stem cells to the target areas in need of treatment in the body. Now, a study from researchers led by DGIST develops a scaffold-based microbot that can precisely deliver stem cells to target body tissue. The team states their research is expected to enhance the treatment of degenerative neural disorders as it can precisely transplant the exact amount of stem cell-based treatment cells to human body tissues and organs.
Previous studies have been conducted using stem cells on animal models of Parkinson’s, Amyotrophic lateral sclerosis, and Alzheimer’s disease, with preliminary studies related to multiple sclerosis being hosted. Clinical and animal studies into the use of stem cells in cases of spinal cord injury have also been completed. However, treatment efficiency and safety are low in all of the aforementioned due to the huge loss of stem cells during delivery, leading to high costs in treatment. The current study develops magnetic microbots for three-dimensional culture and the precise delivery of stem cells in vitro, ex vivo, and in vivo.
The current study manufactures a scaffold microbot in a spherical and helical shape using 3D laser lithography. Results show the microbot minimizes cell loss through a wireless control method using an external magnetic field while transplanting stem cells quickly and precisely at the same time. Data findings show hippocampal neural stem cells attached to the microbots proliferated and differentiated into astrocytes, oligodendrocytes, and neurons successfully.
The microbot was used to transport colorectal carcinoma cancer cells to tumor microtissue on a lab-on-a-chip comprising a liver-tumor micro-organ network. They also extracted a rat’s brain and injected the microbot into the internal carotid artery, transferring it to the anterior cerebral artery and middle cerebral artery using the magnetic field.
The team surmises they have developed a microbot for the precise culture and delivery of stem cells. For the future, the researchers state they plan to develop a microrobot-based precision treatment system which can be used in hospital and clinical sites.
Get Healthinnovations delivered to your inbox:
Michelle Petersen is the founder of Healthinnovations, having worked in the health and science industry for over 21 years, which includes tenure within the NHS and Oxford University. Healthinnovations is a publication that has reported on, influenced, and researched current and future innovations in health for the past decade.
Michelle has been picked up as an expert writer for Informa publisher’s Clinical Trials community, as well as being listed as a blog source by the world’s leading medical journals, including the acclaimed Nature-Springer journal series.
Healthinnovations is currently indexed by the trusted Altmetric and PlumX metrics systems, respectively, as a blog source for published research globally. Healthinnovations is also featured in the world-renowned BioPortfolio, BioPortfolio.com, the life science, pharmaceutical and healthcare portal.
Most recently the Texas A&M University covered The Top 10 Healthinnovations series on their site with distinguished Professor Stephen Maren calling the inclusion of himself and his team on the list a reflection of “the hard work and dedication of my students and trainees”.
Michelle Petersen’s copy was used in the highly successful marketing campaign for the mega-hit film ‘Jumanji: The Next Level, starring Jack Black, Karen Gilian, Kevin Hart and Dwayne ‘The Rock’ Johnson. Michelle Petersen’s copywriting was part of the film’s coverage by the Republic TV network. Republic TV is the most-watched English language TV channel in India since its inception in 2017.
An avid campaigner in the fight against child sex abuse and trafficking, Michelle is a passionate humanist striving for a better quality of life for all humans by helping to provide traction for new technologies and techniques within healthcare.