A new artificial intelligence-based approach can predict, significantly more accurately than a doctor, if and when a patient could die of cardiac arrest. The technology, built on raw images of patient’s diseased hearts and patient backgrounds, stands to revolutionize clinical decision making and increase survival from sudden and lethal cardiac arrhythmias, one of medicine’s deadliest and most puzzling conditions.
The work, led by Johns Hopkins University researchers, is detailed on April 7, 2022, in Nature Cardiovascular Research.
“Sudden cardiac death caused by arrhythmia accounts for as many as 20 percent of all deaths worldwide and we know little about why it’s happening or how to tell who’s at risk,” said senior author Natalia Trayanova, the Murray B. Sachs professor of Biomedical Engineering and Medicine. “There are patients who may be at low risk of sudden cardiac death getting defibrillators that they might not need and then there are high-risk patients that aren’t getting the treatment they need and could die in the prime of their life. What our algorithm can do is determine who is at risk for cardiac death and when it will occur, allowing doctors to decide exactly what needs to be done.”
The team is the first to use neural networks to build a personalized survival assessment for each patient with heart disease. These risk measures provide with high accuracy the chance for a sudden cardiac death over 10 years, and when it’s most likely to happen.
The deep learning technology is called Survival Study of Cardiac Arrhythmia Risk (SSCAR). The name alludes to cardiac scarring caused by heart disease that often results in lethal arrhythmias, and the key to the algorithm’s predictions.
The team used contrast-enhanced cardiac images that visualize scar distribution from hundreds of real patients at Johns Hopkins Hospital with cardiac scarring to train an algorithm to detect patterns and relationships not visible to the naked eye. Current clinical cardiac image analysis extracts only simple scar features like volume and mass, severely underutilizing what’s demonstrated in this work to be critical data.
“The images carry critical information that doctors haven’t been able to access,” said first author Dan Popescu, a former Johns Hopkins doctoral student. “This scarring can be distributed in different ways and it says something about a patient’s chance for survival. There is information hidden in it.”
The team trained a second neural network to learn from 10 years of standard clinical patient data, 22 factors such as patients’ age, weight, race, and prescription drug use.
The algorithms’ predictions were not only significantly more accurate on every measure than doctors, they were validated in tests with an independent patient cohort from 60 health centers across the United States, with different cardiac histories and different imaging data, suggesting the platform could be adopted anywhere.
“This has the potential to significantly shape clinical decision-making regarding arrhythmia risk and represents an essential step towards bringing patient trajectory prognostication into the age of artificial intelligence,” said Trayanova, co-director of the Alliance for Cardiovascular Diagnostic and Treatment Innovation. “It epitomizes the trend of merging artificial intelligence, engineering, and medicine as the future of healthcare.”
The team is now working to build algorithms now to detect other cardiac diseases. According to Trayanova, the deep-learning concept could be developed for other fields of medicine that rely on visual diagnosis.
Reference: “Arrhythmic sudden death survival prediction using deep learning analysis of scarring in the heart” by Dan M. Popescu, Julie K. Shade, Changxin Lai, Konstantinos N. Aronis, David Ouyang, M. Vinayaga Moorthy, Nancy R. Cook, Daniel C. Lee, Alan Kadish, Christine M. Albert, Katherine C. Wu, Mauro Maggioni and Natalia A. Trayanova, 7 April 2022, Nature Cardiovascular Research.
The team from Johns Hopkins also included: Bloomberg Distinguished Professor of Data-Intensive Computation Mauro Maggioni; Julie Shade; Changxin Lai; Konstantino Aronis; and Katherine Wu. Other authors include: M. Vinayaga Moorthy and Nancy Cook of Brigham and Women’s Hospital; Daniel Lee of Northwester University; Alan Kadish of Touro College and University System; David Oyyang and Christine Albert of Cedar-Sinai Medical Center.
The work was supported by National Institutes of Health grants R01HL142496 , R01HL126802, R01HL103812; Lowenstein Foundation, National Science Foundation Graduate Research Fellowship DGE-1746891, Simons Fellowship for 2020-2021, National Science Foundation grant IIS-1837991, Abbott Laboratories research grant. The PRE-DETERMINE study and the DETERMINE Registry were supported by National Heart, Lung, and Blood Institute research grant R01HL091069, St Jude Medical Inc, and St. Jude Medical Foundation.
About Johns Hopkins
The Johns Hopkins University is a private research university in Baltimore, Maryland. Founded in 1876, the university was named for its first benefactor, the American entrepreneur and Quaker philanthropist Johns Hopkins. Johns Hopkins is the oldest research university in the United States.
“What are we aiming at?”
That’s the question our university’s first president, Daniel Coit Gilman, asked at his inauguration in 1876. What is this place all about, exactly? His answer:
“The encouragement of research . . . and the advancement of individual scholars, who by their excellence will advance the sciences they pursue, and the society where they dwell.”
Gilman believed that teaching and research go hand in hand—that success in one depends on success in the other—and that a modern university must do both well. He also believed that sharing our knowledge and discoveries would help make the world a better place.
In 145 years, we haven’t strayed from that vision. This is still a destination for excellent, ambitious scholars and a world leader in teaching and research. Distinguished professors mentor students in the arts and music, humanities, social and natural sciences, engineering, international studies, education, business, and the health professions. Those same faculty members, along with their colleagues at the university’s Applied Physics Laboratory, have made us the nation’s leader in federal research and development funding every year since 1979.
That’s a fitting distinction for America’s first research university, a place that has revolutionized higher education in the U.S. and continues to bring knowledge and discoveries to the world.