A study from researchers at Massachusetts General Hospital (MGH) and Brigham and Women’s Hospital (BWH) reveals for the first time exactly how mutations associated with the most common form of … Continue Reading Study identifies the epigenetic pathway of familial Alzheimer’s disease.
Amyloid, an abnormal protein whose accumulation in the brain is a hallmark of Alzheimer’s disease, starts accumulating inside neurons of people as young as 20, a much younger age than … Continue Reading Alzheimer amyloid accumulation found in young adult brains for the first time.
A unique class of proteins in the human body has the ability to alter their configuration. These so-named intrinsically disordered proteins (IDPs) lack a fixed or ordered three-dimensional structure, which … Continue Reading Researchers investigate how form affects function and aggregation of tau protein in the brain.
The pathological process amyloidosis, in which misfolded proteins, amyloids, form insoluble fibril deposits, occurs in many diseases, including Alzheimer’s disease and type 2 diabetes mellitus. However, little is known about … Continue Reading Researchers identify amyloid formation link between Alzheimer’s disease and T2 diabetes.
Scientists at Rigshopitalet, Herlev Hospital and the University of Copenhagen identify a new biomarker that can predict the risk of developing dementia by way of a simple blood test. In … Continue Reading Large-scale study validates simple blood test for dementia.
When it comes to protecting cells from death brought on by the calamities of environmental stress, the human body is particularly ingenious. From cellular components that suck up misfolded proteins … Continue Reading Key epigenetic phosphorylation pathway identified that protects cells against death by stress.
A new international collaboration led by The University of Montana and Secretaria de la Defensa Naciona heightens concerns over the detrimental impact of the apolipoprotein E (APOE) ε4 allele, the … Continue Reading Decreases in short-term memory and IQ in urban children with ‘Alzheimer’s gene’.
People who carry a variant of a gene that is associated with longevity also have larger volumes in a front part of the brain involved in planning and decision-making, according … Continue Reading Brain region vulnerable to aging is larger in those with longevity gene variant.
Research suggests anti-inflammatory protein, interleukin 10, may trigger plaque in Alzheimer’s disease.
Inflammation has long been studied in Alzheimer’s, but in a counterintuitive finding, University of Florida researchers have uncovered the mechanism by which anti-inflammatory processes may trigger the disease. This anti-inflammatory … Continue Reading Research suggests anti-inflammatory protein, interleukin 10, may trigger plaque in Alzheimer’s disease.
Researchers at the RIKEN-Max Planck Joint Research Center have demonstrated that hallmark symptoms of Alzheimer’s disease can be reduced when sugars are prevented from binding to one of the key … Continue Reading Researchers reduce Alzheimer’s plaques by targeting glycosylation.
Drugs that boost the function of a specific type of neurotransmitter receptor may provide benefit to patients with the second most common type of dementia, according to research by scientists … Continue Reading Scientists boost receptor-function to treat Frontotemporal dementia.