It is known that a 24-hour circadian rhythm controls nearly all brain and body processes, such as the sleep/wake cycle, metabolism, alertness and cognition. These daily activity patterns are regulated … Continue Reading Researchers map the circadian neurogenetics involved in brain aging.
Age is the largest risk factor for numerous pathologies, ranging from neurodegeneration to cancer. These pathologies likely arise from a loss of tissue homeostasis driven by one or more basic … Continue Reading New role for mitochondria identified in cellular senescence and aging.
Alzheimer’s disease poses a health problem of pandemic proportions. It is estimated that by the year 2030 there will be greater than 60 million people worldwide with AD, and $375 … Continue Reading Newly identified role for ApoE explains its effects in Alzheimer’s.
Aging is a major risk factor for many human diseases, and in vitro generation of human neurons is an attractive approach for modeling aging-related brain disorders. While aggressive familial early … Continue Reading New technique enables researchers to grow old human brain cells for the first time.
Telomeres are repetitive nucleotide sequences located at the termini of chromosomes. Telomere shortening in humans can induce cellular old-age, which blocks cell division. This mechanism prevents genomic instability and development … Continue Reading Researchers identify new enzyme critical to maintaining human telomere length.
An estimated seven to ten million people worldwide are living with Parkinson’s disease (PD), which is an incurable and progressive disease of the nervous system affecting movement and cognitive function. … Continue Reading Study first to link immunogenetics to non-familial Parkinson’s disease.
Cognitive function is known to change during normal aging and in age-related disease such as Alzheimer’s disease. Although the exact cause for age-related cognitive decline is not clear, recent studies … Continue Reading Researchers combat memory loss by enhancing brain function in animal model.
An enzyme called telomerase plays a significant role in aging and most cancers. Telomerase’s primary job is to maintain the DNA in telomeres, the structures at the ends of a … Continue Reading Study provides previously unseen structure of telomere-controlling enzyme.
Neural stem cells generate new neurons throughout life in the mammalian brain. Neural stem cells are self-renewing, multipotent cells that generate the main phenotype of the nervous system. Stem cells … Continue Reading Researchers identify neuroprotective mechanism against stem cell aging.
Alzheimer’s is the most common form of dementia, causing problems with memory, thinking and behaviour. Symptoms usually develop slowly and get worse over time as it is a progressive disease; … Continue Reading Largest ever human trial shows resveratrol impacts Alzheimer’s biomarker.
Today, more than 5.1 million Americans live with Alzheimer’s disease, a devastating type of dementia that plagues memory and thinking. That number is expected to triple in the coming decades. … Continue Reading Work begins on turning an ApoE4 Alzheimer’s brain into an ApoE2 Alzheimer’s brain.
As humans grow older, they lose strength and muscle mass. Skeletal muscle weakness and atrophy are among the most pervasive and disruptive effects of aging. In nearly all people, even … Continue Reading Researchers identify precise cause of muscle weakness and loss due to aging.
In human cells, shortened telomeres, the protective caps at the ends of chromosomes, are both a sign of aging and contribute to it. The effects of chronic diseases such as … Continue Reading Researchers use dietary supplement in atherosclerotic mice to lengthen telomeres.
Free radicals are especially reactive atoms or groups of atoms that have one or more unpaired electrons. They are produced in the body as a by-product of normal metabolism and … Continue Reading New findings on the free radical theory of aging and mitochondrial damage.
Studying telomeres, the structures that protect the ends of chromosomes, has become a key issue in biology. In recent years, not only has their relation to aging been confirmed; defective … Continue Reading Extensive review maps all known diseases caused by defective telomeres.
Practically everyone gets fatter as they get older, however, according to a new study from researchers at Duke University some people can blame their genes for the extra padding. The … Continue Reading Researchers identify gene responsible for obesity and diabetes in old age.