Category Archives: APOE4

Study shows how Alzheimer’s risk gene disrupts memory replay.

It is known that one of the earliest sites of Alzheimer’s disease pathology is the hippocampus, a brain structure critical for the learning and memory processes that falter early in Alzheimer’s disease.  The apoE4 gene creates a protein of the same name that markedly increases a person’s risk for Alzheimer’s disease and occurs in 65%-80% of people with Alzheimer’s disease.  ApoE4

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