Researchers have long explored ways to transplant pancreatic islets to treat type I diabetes in the long term to eliminate the need for continuous glucose monitoring and insulin injections. However, … Continue Reading Tiny drug-delivering capsules could sustain transplanted insulin-producing cells.
Type I diabetes is a disease with two parts, firstly, the beta cells are killed by the body’s own immune system, and then secondly they fail to regenerate, causing the … Continue Reading Previously unknown type of regenerating insulin-producing cell discovered.
Crohn’s disease, a common inflammatory disorder of the intestinal tract, can have devastating consequences for a patient’s quality of life. Although people with the disease are typically treated with powerful … Continue Reading Researchers identify 2 distinct genetic subtypes in Crohn’s disease patients.
It is known that patients with Crohn’s disease have uncontrolled inflammation in their gut, which can lead to intestinal fibrosis and narrowing that can slow or block the movement of … Continue Reading Study identifies immune cells critical for the development of fibrosis in Crohn’s disease.
The inflammatory response is an integral part of the innate immune mechanism that is triggered in response to a real or perceived threat to tissue homeostasis, with a primary aim … Continue Reading New class of molecule identified in central role of inflammation and the immune system.
Diabetes is a chronic condition that causes high blood sugar levels that are potentially fatal if left unmanaged. Injection of insulin is the primary treatment against this disease. Unfortunately a … Continue Reading New insulin pill successful in animal studies.
Demyelinating diseases, such as multiple sclerosis and leukodystrophy, are characterized by damage to the protective myelin sheath that surrounds the axons of neurons. This demyelination can be caused by an … Continue Reading Cell therapy successfully promotes axon remyelination in an animal model.
Patients suffering from so-called immune-mediated neuropathies frequently have a long medical record. As there are no diagnostic tests available to reliably diagnose the disease, the diagnosis is frequently made belatedly … Continue Reading Study identifies previously unknown cause of immune neuropathy.
When the body is fighting an invading pathogen, white blood cells, including T cells, must respond. T-cell receptors (TCRs) recognize pathogens during T-cell–mediated adaptive immune responses. The binding between TCRs … Continue Reading New imaging provides unprecedented detail of immune cells’ surface.
HIV, is a virus that attacks the body’s immune system. If left untreated, HIV can progress and develop into AIDS. HIV infection is enhanced by adhesive structures that form between … Continue Reading First-ever study captures HIV cell-to-cell transmission in a living animal.
A person’s genetic makeup plays a role in autoimmune diseases such as multiple sclerosis that develop when the body is attacked by its own immune system. However, little is known … Continue Reading Study maps gene variants to DNA regions that regulate immune cells.
Multiple sclerosis (MS) is a neurodegenerative disease in which the immune system attacks the myelin that protects nerve fibers, upsetting the flow of information between the brain and the body. … Continue Reading Human study identifies the genetic cause of familial multiple sclerosis.
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterised by abdominal pain and altered bowel habits. IBS has a high prevalence of up to 15% among the general population … Continue Reading Breath-test used to diagnose irritable bowel syndrome in large human study.
Genetic susceptibility is thought to play a role in common diseases including those affecting the colon such as inflammatory bowel diseases (IBD) and colorectal cancer. As is the case for … Continue Reading Study shows how gut microbiota interact with genes to promote Crohn’s disease.
Allergies are characterized by inappropriate inflammatory responses to benign environmental antigens. Primary clinical approaches to allergic disease consist of symptom control or administration of soluble antigens to skew the immune response … Continue Reading Novel nanoparticle acts like Trojan horse to halt asthma in animal model.
Systemic lupus erythematosus (SLE) is a common autoimmune disorder in which the body’s immune system mistakenly attacks healthy tissues, it can affect the skin, joints, kidneys, brain, and other organs. … Continue Reading Study shows how mitochondria drives autoimmune response in lupus.