Category Archives: chromosome

Mystery solved as protein expressed in response to telomere shortening identified.

Telomeres are critical for maintaining genomic integrity with telomere dysfunction or shortening commonly acquired during the process of tumour development.  To add to this cancer cells require a mechanism to elongate their telomeric DNA in order to continue dividing indefinitely. A mechanism for telomere elongation is one of the key steps in cellular immortalization. Zscan4 is a DNA-binding protein that

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