Pain hypersensitivity can spread to unaffected body regions immediately surrounding the initial insult. Sometimes it can even spread to the opposite site of the body or to large body areas … Continue Reading Pain-initiating function of glial cells identified for the first time.
Neuropathic pain is deﬁned as pain initiated or caused by a primary lesion or dysfunction in the nervous system. Chronic neuropathic leg pain is the most common form of neuropathic … Continue Reading Neuroimaging shows that spinal cord stimulation reduces emotional aspect of chronic pain.
In the treatment of pain, a common course is to treat patients with opioid medications, these medications show limited effectiveness for neuropathic pain and come with safety and addiction issues. … Continue Reading Researchers map how antidepressants lessen neuropathic pain.
Diabetic neuropathy is a condition in which perpetually high blood sugar causes nerve damage, resulting in a myriad of symptoms such as numbness, reduced ability to detect painful stimuli, muscle … Continue Reading Stem cell injections improve diabetic neuropathy in animal models.
Brain inflammation caused by chronic nerve pain alters activity in regions that regulate mood and motivation, suggesting for the first time that a direct biophysical link exists between long-term pain … Continue Reading Researchers link microglia activation triggered by chronic pain to anxiety and depression.
A new literature review study from researchers at the University of Tel Aviv has found that people with dementia and other forms of cognitive impairment have altered responses to pain, with … Continue Reading Lit review study finds altered pain processing in patients with cognitive impairment.
A chemical in the brain typically associated with cognition, movement and reward-motivation behaviour, among others, may also play a role in promoting chronic pain, according to new research from researchers … Continue Reading Researchers map dopamine based chronic-pain pathway in the spinal cord and brain.
Researchers successfully implant and control light-sensitive opioid receptors in mice via optogenetics.
Despite the abuse potential of opioid drugs, they have long been the best option for patients suffering from severe pain. The drugs interact with receptors on brain cells to tamp … Continue Reading Researchers successfully implant and control light-sensitive opioid receptors in mice via optogenetics.
A protein that normally fosters tissue repair instead acts to inhibit healing when sugar levels are high, according to a study in The Journal of Cell Biology. The data findings … Continue Reading Researchers map epigenetic cause of slowed diabetic wound healing.
In a new study from Saint Louis University, researchers discovered that drugs targeting the A3 adenosine receptor can turn off pain signals in the spinal cord to provide relief from … Continue Reading Researchers use A3 adenosine receptors to activate ‘off signals’ for chronic pain.
Researchers from the University of Bern have discovered a mechanism that is responsible for the level of chronic pain in the brain. The results of this study point to new … Continue Reading Researchers begin to map chronic pain memory in the brain.
Pain is a common nonmotor symptom in patients with Parkinson disease and it negatively impacts quality of life. Patients with Parkinson disease who experienced pain before undergoing subthalamic nucleus deep … Continue Reading Eight-year study assesses efficacy of DBS on pain in patients with Parkinson’s disease.
Sensing pain is extremely unpleasant and sometimes hard to bear, and pain can even become chronic. The perception of pain varies a lot depending on the context in which it … Continue Reading Researchers map the neurons and connections involved in the Gate Control Theory of pain.
Pain is the body’s protective mechanism and a complex neurological phenomenon. Moreover, ongoing pain in the sense of chronic pain can be a disease. Scientists from Technische Universität München (TUM) … Continue Reading Neuroimaging study shows brain processes ongoing pain more emotionally.
Medical marijuana is proliferating across the country due to the ability of cannabis ingestion to treat important clinical problems such as chronic pain. However, negative side effects and the development … Continue Reading Cannabinoid CB2 receptors suppress neuropathic pain with no signs of physical dependence in study.
New research from The University of Queensland shows that seven compounds of the countless found in spider venom block a key step in the body’s ability to pass pain signals … Continue Reading Analysis of spider venom reveals multiple compounds with potential to relieve chronic pain.