A primary function of cytokines is to initiate immune responses; however, it has become increasingly apparent that they play major roles in the regulation of energy homeostasis, implicating them in metabolic disease.  One such cytokine is interleukin-18 (IL-18). Obese individuals have increased levels of IL-18 that correlate strongly with metabolic syndrome and insulin resistance.  Recent evidence suggests that IL-18 acts to trigger AMP-activated protein kinase … Continue reading Sensor protein shown to have dual role in immune-system and metabolism.