It has long been known that transcriptional regulation during embryonic development relies on the regulation of thousands of genes. Within a particular cell type defined sets of DNA-binding transcription factors … Continue Reading Researchers map how transcription factors interact to create a heart.
Caring for patients with heart failure costs the United States $40 billion a year. Despite the condition’s enormous impact, few new treatments have been developed, and those that exist produce … Continue Reading Human study identifies sleep gene linked to heart failure.
Thyroid cancer, the most common cancer of the endocrine glands, is the fastest rising cancer in women and second fastest rising in men in the U.S. Thyroid cancer is a … Continue Reading Researchers identify a new thyroid cancer gene via another disease.
Growing insights about a significant part of the genome, the dark matter of DNA, have fundamentally changed the way scientists approach the study of diseases. The human genome contains about … Continue Reading Study provides first ever comprehensive profile of lncRNAs in human cancers.
Antigen receptor genes are assembled by controlled, large-scale deletions and inversions. Errors in this process, known as V(D)J recombination, produce aberrant genomic rearrangements, which can fuel the development of T- … Continue Reading Researchers identify points where incorrect immune cell DNA editing causes blood cancer.
Synapses are specialized, protein-rich cell junctions that are essential for normal brain function and are dysfunctional in many diseases and disorders of the nervous system. Synapses are made up of … Continue Reading Study identifies elusive master regulator of synaptic protein sorting.
Dividing cells are prone to errors, and so they must be prepared to summon sophisticated emergency systems to deal with potential damage. One type of division-derailing mishap can occur when … Continue Reading Researchers identify previously unknown part of the ICL DNA repair pathway.
Worldwide, close to a million cases of gastric cancers are diagnosed each year with some of the world’s highest incidence rates are in Asia (particularly in Korea, Japan and China). … Continue Reading Researchers identify recurrent fusion genes responsible for gastric cancer initiation.
A study to examine recessively inherited genome-wide DNA sequences has for the first time discovered a potential link with Britain’s biggest killer, Coronary Artery Disease (CAD). The research led by … Continue Reading Researchers identify the link between inherited DNA sequences and heart disease.
Acute liver failure is a rare yet life-threatening disease for young children. It often occurs extremely rapidly, for example, when a child has a fever. Yet in around 50 percent … Continue Reading Researchers identify new gene responsible for liver disease.
Infectious diseases such as hepatitis C and some of the world’s deadliest superbugs, C. difficile and MRSA among them, could soon be detected much earlier by a unique diagnostic test, … Continue Reading Researchers develop world’s most sensitive universal diagnostic test for all disease.
Researchers at the University of Bonn and the German Center for Infection Research (DZIF) have discovered two new groups of viruses within the Bunyavirus family in the tropical forest of … Continue Reading Researchers have discovered two new groups of viruses.
A new test co-developed by a Boston University School of Medicine (BUSM) researcher will allow patients suspected of having lung cancer to be subjected to fewer and less-invasive tests to … Continue Reading Large-scale human trials validates the use of genomic-based test for lung cancer detection.
DNA (deoxyribonucleic acid) is the main component of human genetic material. It is formed by combining four parts known as Adenine (A), Cytosine (C), Guanine (G) and Thymine (T) respectively. … Continue Reading Researchers state they have discovered the sixth DNA base in eukaryotes.
RNA is both the bridge between DNA and the production of proteins known to carry out the functions of life, guiding the amount and type of protein mades. As messenger … Continue Reading The first ever study to map splicing changes during T cell development has been published.
In results presented at the American Association for Cancer Research (AACR) Annual Meeting 2015, a collaborative study by the University of Colorado and the National Cancer Institute (NCI) reports that … Continue Reading Precision medicine study shows the most frequently altered gene in bladder cancer.