Scientists at The Scripps Research Institute (TSRI) have discovered that a gene mutation linked to hereditary spastic paraplegia, a disabling neurological disorder, interferes with the normal breakdown of triglyceride fat molecules in the brain. The TSRI researchers found large droplets of triglycerides within the neurons of mice modelling the disease. The findings, reported ahead of print by the journal Proceedings of the National Academy of … Continue reading Scripps Research Institute scientists shed light on cause of spastic paraplegia.