The inflammatory response is an integral part of the innate immune mechanism that is triggered in response to a real or perceived threat to tissue homeostasis, with a primary aim … Continue Reading New class of molecule identified in central role of inflammation and the immune system.
The WHO recommends complete withdrawal of the oral polio vaccine (OPV) by April 2016 globally and replacing with at least one dose of inactivated poliovirus vaccine (IPV). However, high-cost, limited … Continue Reading Researchers develop plant-based Polio booster vaccine.
Alzheimer’s disease is a devastating and progressive neurodegenerative disease affecting approximately 5.3 million people in the United States, including almost half of the population at 85 years and older. Microscopic hallmarks … Continue Reading New blood test detects early Alzheimer’s in large-scale study with unprecedented sensitivity.
Acute HIV-1 infection is the phase of HIV-1 disease immediately after infection that is characterized by an initial burst of viremia; although anti-HIV-1 antibodies are undetectable, HIV-1 RNA or p24 … Continue Reading Study captures HIV study early to successfully characterise the elusive acute infection period.
A person’s genetic makeup plays a role in autoimmune diseases such as multiple sclerosis that develop when the body is attacked by its own immune system. However, little is known … Continue Reading Study maps gene variants to DNA regions that regulate immune cells.
A fundamental question in human immunodeficiency virus 1 (HIV-1) research is why the immune system is unable to contain the virus. Unlocking this key would provide a significant advance in … Continue Reading New study explains why HIV is not cleared by the immune system.
Allergies are characterized by inappropriate inflammatory responses to benign environmental antigens. Primary clinical approaches to allergic disease consist of symptom control or administration of soluble antigens to skew the immune response … Continue Reading Novel nanoparticle acts like Trojan horse to halt asthma in animal model.
Systemic lupus erythematosus (SLE) is a common autoimmune disorder in which the body’s immune system mistakenly attacks healthy tissues, it can affect the skin, joints, kidneys, brain, and other organs. … Continue Reading Study shows how mitochondria drives autoimmune response in lupus.
The earliest events that occur following mucosal HIV-1 exposure remain poorly understood, largely because the eclipse period of infection prior to the detectable disease is very difficult to study in … Continue Reading Earliest ever events following HIV infection mapped for the first time.
Psoriasis is a chronic autoimmune disorder that affects 2% of the world population. It is characterised by inflammation and scaling of the skin, accompanied by a greater risk of contracting … Continue Reading Researchers identify a link between psoriasis and bone loss.
In recent years, Ebola outbreaks have increased in frequency, duration, and geographical spread, underscoring the need for pre- and post-exposure treatments. Antibodies targeting the Ebola virus surface glycoprotein, the viral structure … Continue Reading Previously unknown ebola-fighting antibodies identified in outbreak survivor’s blood.
The peripheral nervous system is a vast network of nerves that exists primarily outside of brain and spinal cord and connects to the far reaches of the body. The very … Continue Reading Study shows how protein promotes regeneration of injured peripheral nerves.
It is known that chronic inflammation in the gut increases the risk of colon cancer by as much as 500%. Therefore, the genetic basis and mechanism of cancer proliferation in … Continue Reading Researchers show how gut inflammation initiates colon cancer.
When pathogens infect the cells of the body, the infection sets off a chain reaction involving the immune system that changes the expression of hundreds of genes. Gene expression is … Continue Reading Multiple signatures left on the immune system by viral infections identified for the first time.
An estimated seven to ten million people worldwide are living with Parkinson’s disease (PD), which is an incurable and progressive disease of the nervous system affecting movement and cognitive function. … Continue Reading Study first to link immunogenetics to non-familial Parkinson’s disease.
An estimated 100,000 Canadians live with multiple sclerosis; there is currently no cure for the disease. Modern scientific understanding has considered multiple sclerosis (MS) to be a disease controlled by the … Continue Reading Specific subset of b-cell responsible for Multiple Sclerosis disease activity identified.