Antigen receptor genes are assembled by controlled, large-scale deletions and inversions. Errors in this process, known as V(D)J recombination, produce aberrant genomic rearrangements, which can fuel the development of T- and B-cell malignancies. Now, a study from researchers at the University of Pennsylvania have shown that when V(D)J recombinase, hits so-called ‘off-target’ spots on a chromosome, the development of immune cells can lead to cancer … Continue reading Researchers identify points where incorrect immune cell DNA editing causes blood cancer.