Category Archives: malignant pleural mesothelioma

Next generation sequencing used to map epigenetic methylation in malignant pleural mesothelioma.

Next generation sequencing in malignant pleural mesothelioma (MPM) tumours shows a complex mutational setting with a high number of genetic alterations in genes involved in DNA repair, cell survival and cell proliferation pathways. Increased accumulation of epigenetic methylation/DNA mutations correlates with early progression of the tumour and decreased survival. MPM is a fatal cancer associated with asbestos exposure that develops

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