Acting as natural computers, our brains contain trillions of cells to store memory and control the body’s functions and emotions. Around one in ten of the countless cells in the … Continue Reading Microglia filmed shaping synapses for the first time.
Alzheimer’s disease (AD) is the most common dementia type, with no treatment to slow down the progression of this dehumanizing disease currently available. The mechanisms of AD are poorly understood … Continue Reading Astrocytes linked to Alzheimer’s disease for the first time.
During brain development, the formation of neuronal synapses at the right time, the right place, and the right strength are crucial to the ongoing function of the brain throughout life. … Continue Reading Astrocytes regulate the formation of synapses in neurodevelopment.
The brain consists of two major types of cells, namely neurons and glial cells, with the immune-based glial cells providing support and protection for neurons in the central and peripheral … Continue Reading Study identifies previously unknown role of microglia in neurodevelopment.
Pain hypersensitivity can spread to unaffected body regions immediately surrounding the initial insult. Sometimes it can even spread to the opposite site of the body or to large body areas … Continue Reading Pain-initiating function of glial cells identified for the first time.
A significant milestone in the evolution of the mammalian brain is the emergence of the corpus callosum, which is exclusively present in placental mammals. This commissure forms the largest axon … Continue Reading Neuroimaging shows that astrocytes are responsible for joining the 2 halves of the brain together.
Demyelinating diseases, such as multiple sclerosis and leukodystrophy, are characterized by damage to the protective myelin sheath that surrounds the axons of neurons. This demyelination can be caused by an … Continue Reading Cell therapy successfully promotes axon remyelination in an animal model.
It is known that repeated cocaine-use results in the development of behavioural sensitization, accompanied by a decrease in excitatory synaptic strength in the nucleus accumbens (NAc). Furthermore, glial cells in … Continue Reading Microglia-based mechanism that reduces effect of cocaine on the brain identified.
The hippocampus is a critical structure for encoding of novel experiences. A particularly compelling puzzle is how the hippocampus encodes new information in the presence of interference from past memories. … Continue Reading Neuroimaging shows how the brain switches from past to present memory mode.
Whenever a person learns something new or is affected by their experiences it’s because synapses, the connections between neurons in the brain, have changed. Sometimes new synapses are made, and … Continue Reading Study shows how astrocytes help control synapse strength and plasticity.
It is known that Parkinson’s disease, the second most common neurodegenerative disease, has genetic causes in 15% of cases. It has been shown that premature aging of dopaminergic neurons in the … Continue Reading Study shows how defective gene prematurely ages neurons in Parkinson’s disease.
It is known that Amyotrophic Lateral Sclerosis (ALS) gradually kills nerve cells in the brain and spinal cord. It is one of the most prevalent neuromuscular diseases, resulting in more … Continue Reading Study shows microglia has a direct role in the development of Lou Gehrig’s disease.
Astrocytes are star-shaped cells in the brain that surround brain cells, known as neurons, protecting them from injury and enabling them to function properly. The brain contains billions of cells, … Continue Reading Study breaks new ground on the role and formation of astrocytes in the brain.
When the blood-brain barrier (BBB) is breached the brain becomes vulnerable to infection and injury. Therefore, it’s imperative that the openings in the BBB are resealed quickly. This most frequently … Continue Reading Researchers identify new role for microglia in blood-brain barrier maintainence.
Astrocytes are star-shaped glial cells in the brain and spinal cord. They perform many functions, including biochemical support of endothelial cells that form the blood–brain barrier, provision of nutrients to … Continue Reading Researchers purify and grow human astrocytes-in-a-dish for the first time ever.
Obesity increases risk of age-related cognitive decline and is accompanied by peripheral inflammation. Studies in rodent models of obesity have demonstrated that impaired hippocampal function correlates with microglial activation, however, … Continue Reading Study shows obesity causes microglia to start eating neural connections.