One of the world’s most deadly diseases, tuberculosis, primarily a lung disease, infects more than 8 million people and is responsible for 1.5 million deaths each year. According to the … Continue Reading Previously unknown method of tuberculosis infection identified.
The WHO recommends complete withdrawal of the oral polio vaccine (OPV) by April 2016 globally and replacing with at least one dose of inactivated poliovirus vaccine (IPV). However, high-cost, limited … Continue Reading Researchers develop plant-based Polio booster vaccine.
HIV, is a virus that attacks the body’s immune system. If left untreated, HIV can progress and develop into AIDS. HIV infection is enhanced by adhesive structures that form between … Continue Reading First-ever study captures HIV cell-to-cell transmission in a living animal.
African sleeping sickness is caused by the single-cell parasite Trypanosoma brucei and is spread by infected tsetse flies in sub-Saharan Africa. The disease is deadly, affecting both humans and livestock … Continue Reading Previously unknown protective enzyme identified in the sleeping sickness parasite.
The earliest events that occur following mucosal HIV-1 exposure remain poorly understood, largely because the eclipse period of infection prior to the detectable disease is very difficult to study in … Continue Reading Earliest ever events following HIV infection mapped for the first time.
Brazil is in the midst of an unprecedented epidemic of Zika virus (ZIKV), a flavivirus that is transmitted by mosquitoes and sexually, which was first detected in the country in … Continue Reading New research provides mechanism and evidence of how Zika virus causes microcephaly in newborns.
Envelope glycoprotein GP120 is a glycoprotein exposed on the surface of the HIV envelope (ENV). The envelope glycoprotein trimer is essential for HIV entry into cells as it plays a … Continue Reading New breakthrough imaging shows HIV structure in unprecedented detail.
The MERS coronavirus (MERS-CoV) was first isolated from the sputum of a patient who died of respiratory and renal failure in Saudi Arabia in 2012. Since then, more than three-quarters … Continue Reading First-ever autopsy of patient with MERS provides unprecedented clinical insights.
When pathogens infect the cells of the body, the infection sets off a chain reaction involving the immune system that changes the expression of hundreds of genes. Gene expression is … Continue Reading Multiple signatures left on the immune system by viral infections identified for the first time.
How HIV-1 overcomes the person’s defenses and infects their cells has been studied intensively for over 30 years. While much has been learned, there remain events in the viral life … Continue Reading Researchers reveal and image new phase of HIV infection for the first time.
Malaria infection starts when the sporozoite stage of the Plasmodium parasite is injected into the skin by a mosquito. Sporozoites are known to traverse host cells before finally invading a … Continue Reading Previously unknown interaction between malaria parasites and liver cells identified.
Herpes simplex virus (HSV) is found in the brain cells of approximately 90% of the world’s population and leads to cold sores, recurrent eye infections, genital lesions, and in rare … Continue Reading Study shows how the herpes simplex virus reactivates in neurons.
Bacteriophages are abundant in the environment, which means they are ecologically friendly. They infect and kill only bacteria, which means they could be used as novel biocontrol agents and even … Continue Reading Bacteriophage decontaminates infant formula infected with superbug.
A young woman now aged 18 and a half, who at birth was HIV-infected via mother-to-child transmission (during pregnancy or at delivery), is in virological remission, despite not having taken … Continue Reading World’s first case of long-term remission (12 years) in an HIV-infected child to be presented.
A collaborative team from The University of Texas and the National Institutes of Health have developed an inhalable vaccine that successfully protects primates against Ebola in simian trials. The team … Continue Reading First ever inhalable ebola vaccine is successful in simian trials.
Infectious diseases such as hepatitis C and some of the world’s deadliest superbugs, C. difficile and MRSA among them, could soon be detected much earlier by a unique diagnostic test, … Continue Reading Researchers develop world’s most sensitive universal diagnostic test for all disease.