Category Archives: Primary Progressive Aphasia

Neuroimaging can identify start and location of amyloid plaques in living brain.


Primary progressive aphasia (PPA) is a form of dementia characterized by degeneration of the language network.  In the early stages, PPA is associated with a left-lateralized pattern of cortical atrophy most commonly leading to frontotemporal degeneration, followed by Alzheimer’s disease.  PPA patients with Alzheimer’s disease generally show a different pattern of neurofibrillary tangles than beta-amyloid plaques, with varying distribution in the

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