More than 600,000 patients in the United States alone suffer from end-stage liver disease, or cirrhosis. The only available cure is liver transplantation, but the shortage of donor livers means … Continue Reading New approach repairs living liver from within with no need of cell transplants.
Red blood cells are the most abundant cells in the human body, and transport oxygen and carbon dioxide. Millions of people worldwide suffer from anaemia, a condition in which the … Continue Reading Study identifies the genetic code of red blood cells.
Mesenchymal stem cells (MSCs) are among the major stem cells used for cell therapy and regenerative medicine. In-vivo cell-tracking by magnetic resonance imaging (MRI) is crucial for regenerative medicine, allowing … Continue Reading Biomimetic method produces large numbers of MRI-trackable mesenchymal stem cells.
Tails in lizards and arms in starfish show an astounding ability to regrow, however, mammals have partially lost the capacity to extensively regenerate body parts. The liver is unique among … Continue Reading Researchers use epigenetic mechanism to regenerate mammalian liver.
Research into bioengineering has led to important achievements in recent years, with a number of different tissue types being developed. In the area of skin tissue epithelial cells have been … Continue Reading Researcher successfully grow complex, implantable, skin tissue for the first time.
In humans, the surgical removal of an ovary or ovaries is most often performed due to diseases such as ovarian cysts or cancer, or in conjunction with hysterectomy. In the … Continue Reading 3D-printed ovary bioprosthesis restores fertility in mice.
Damage to axons in the central nervous system (CNS) typically results in permanent damage and severed axons in the adult mammalian CNS do not spontaneously regenerate to restore lost functions. … Continue Reading Researchers regenerate damaged nerves via the eye using optogenetics.
Wound repair is an important aspect of physiology, and disruption of this process can result in a number of defects involving wound healing, chronic ulceration and scarring. A scar on … Continue Reading Study pinpoints protein that helps to regulate wound healing.
Adult stem cells provide the body with a reservoir from which damaged or used up tissues can be replenished. In organs like the intestines and skin, which need constant rejuvenating, … Continue Reading Study verifies how stem cells get activated to produce new hair.
It is known that the age-related growth differentiation factor 11 (GDF11) is member of the transforming growth factor β superfamily of proteins. Circulating GDF11 concentrations appear to decline with age, … Continue Reading Study identifies previously unknown molecular pathway in aging.
It is known that the regenerative capacity of the injured central nervous system (CNS) in adult mammals is severely limited, yet axons in the peripheral nervous system (PNS) regrow, albeit … Continue Reading Gene pathway responsible for peripheral nervous system regeneration identified.
The peripheral nervous system is a vast network of nerves that exists primarily outside of brain and spinal cord and connects to the far reaches of the body. The very … Continue Reading Study shows how protein promotes regeneration of injured peripheral nerves.
In humans, up to half of body mass is made up of skeletal muscle, which plays a key role in locomotion, posture, and breathing. Although skeletal muscles can overcome minor … Continue Reading Biologic-free mechanically induced muscle regeneration successful in animal studies.
Kidney failure is a growing problem in the United States, every year, approximately 10,000 kidneys become available for transplant into patients with end-stage kidney disease. However, the waiting lists for … Continue Reading Mammalian kidney identified as a ‘blood-generating’ organ for the first time.
Mammalian skeletal muscles can regenerate following injury and this response is mediated by a specific type of stem cell, the satellite cell. Significant evidence suggests that while stem cells represent … Continue Reading Previously unknown mechanism in skeletal muscle regeneration identified.
In the field of iPS cell-based regenerative medicine, advanced research with clinical applications for many organs and tissues, such as the retina, has steadily progressed. However, growing a kidney from … Continue Reading Human stem cell-derived kidneys connect to blood vessels when transplanted into mice.