For decades, scientists have known that people with two copies of a gene called apolipoprotein E4, or ApoE4, are much more likely to have Alzheimer’s disease at age 65 than … Continue Reading Study shows why people with the ApoE4 gene are more susceptible to Alzheimer’s disease.
It is known that during disease, tau protein gets modified, changes its location in nerve cells and then aggregates. In healthy nerve cells, tau resides in a part of the … Continue Reading Previously unknown tau pathway leading to Alzheimer’s disease identified.
In Alzheimer’s, a build-up of plaque and dysfunctional proteins in the brain are known to be hallmarks of the disease. While the majority of Alzheimer’s research has focused on accumulation … Continue Reading New technique reveals that tau predicts Alzheimer’s disease progression.
It has been known for some years that Alzheimer’s disease is characterised by two types of lesions, amyloid plaques and degenerated tau protein. The amyloid component and altered cholesterol metabolism … Continue Reading Study shows link between the tau component of Alzheimer’s and cholesterol.
Examining post-mortem tissue from the brains of people with Alzheimer’s disease, Stanford University researchers state they have identified what appear to be iron-containing microglia, specialized scavenger cells that sometimes become … Continue Reading A human study identifies region specific iron-containing microglia in Alzheimer’s brains.
A unique class of proteins in the human body has the ability to alter their configuration. These so-named intrinsically disordered proteins (IDPs) lack a fixed or ordered three-dimensional structure, which … Continue Reading Researchers investigate how form affects function and aggregation of tau protein in the brain.
Drugs that boost the function of a specific type of neurotransmitter receptor may provide benefit to patients with the second most common type of dementia, according to research by scientists … Continue Reading Scientists boost receptor-function to treat Frontotemporal dementia.
An experimental positron emission tomography (PET) tracer is effective in diagnosing concussion-related brain disease while a person is still alive, according to a case study conducted at the Icahn School … Continue Reading Neuroimaging technique identifies concussion-related brain disease in living brain.