Category Archives: TDP-43

Researchers identify the mechanism of protein clumps in the brain of patients with ALS.


Almost a decade ago scientists first described the clumps of TDP-43 that commonly appear in the degenerated brain or nerve cells of those with FTD or ALS.  However, whether the clumps were a cause or an effect of the diseases, and exactly what they did, was unknown.  Postmortem histology of nearly every patient with the lethal neurodegenerative disorder amyotrophic lateral

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