Almost a decade ago scientists first described the clumps of TDP-43 that commonly appear in the degenerated brain or nerve cells of those with FTD or ALS.  However, whether the clumps were a cause or an effect of the diseases, and exactly what they did, was unknown.  Postmortem histology of nearly every patient with the lethal neurodegenerative disorder amyotrophic lateral sclerosis (ALS), and many with … Continue reading Researchers identify the mechanism of protein clumps in the brain of patients with ALS.