A significant milestone in the evolution of the mammalian brain is the emergence of the corpus callosum, which is exclusively present in placental mammals. This commissure forms the largest axon … Continue Reading Neuroimaging shows that astrocytes are responsible for joining the 2 halves of the brain together.
It is known that patients with Crohn’s disease have uncontrolled inflammation in their gut, which can lead to intestinal fibrosis and narrowing that can slow or block the movement of … Continue Reading Study identifies immune cells critical for the development of fibrosis in Crohn’s disease.
The inflammatory response is an integral part of the innate immune mechanism that is triggered in response to a real or perceived threat to tissue homeostasis, with a primary aim … Continue Reading New class of molecule identified in central role of inflammation and the immune system.
Generally, researchers divide the human immune system into two parts. One part, called the innate immune system, allows for immediate and direct recognition of invading bacteria. It prompts immune cells … Continue Reading Study identifies previously unknown mechanism of the immune system.
Allergies are characterized by inappropriate inflammatory responses to benign environmental antigens. Primary clinical approaches to allergic disease consist of symptom control or administration of soluble antigens to skew the immune response … Continue Reading Novel nanoparticle acts like Trojan horse to halt asthma in animal model.
Systemic lupus erythematosus (SLE) is a common autoimmune disorder in which the body’s immune system mistakenly attacks healthy tissues, it can affect the skin, joints, kidneys, brain, and other organs. … Continue Reading Study shows how mitochondria drives autoimmune response in lupus.
Infection and inflammation during pregnancy have been associated with adverse outcomes, such as preterm birth, abortion, and postnatal cognitive disorders. Yet how microbial products circulating in the maternal bloodstream affect … Continue Reading Study shows maternal bacterial infections trigger abnormal neurogenesis in fetal brain.
Macrophages, also known as scavenger cells, are immune cells which are part of the innate immune system and differentiate from monocytes. They circulate in the bloodstream and upon differentiation, invade … Continue Reading New study refutes textbook theory on macrophage metabolism.
Psoriasis is a chronic autoimmune disorder that affects 2% of the world population. It is characterised by inflammation and scaling of the skin, accompanied by a greater risk of contracting … Continue Reading Researchers identify a link between psoriasis and bone loss.
The immune system exercises constant vigilance to protect the body from external threats, including what the person eats and drinks. A careful balancing act plays out as digested food travels … Continue Reading Study finds neurons in gut regulate the immune system to control inflammation.
When the blood-brain barrier (BBB) is breached the brain becomes vulnerable to infection and injury. Therefore, it’s imperative that the openings in the BBB are resealed quickly. This most frequently … Continue Reading Researchers identify new role for microglia in blood-brain barrier maintainence.
Obesity increases risk of age-related cognitive decline and is accompanied by peripheral inflammation. Studies in rodent models of obesity have demonstrated that impaired hippocampal function correlates with microglial activation, however, … Continue Reading Study shows obesity causes microglia to start eating neural connections.
The standard model of natural selection predicts that once the age of reproduction ends, individuals die. That’s because selection early in life strongly favors variants that benefit reproductive success, even … Continue Reading Study identifies gene variants which protect older adults from neurodegeneration.
An estimated seven to ten million people worldwide are living with Parkinson’s disease (PD), which is an incurable and progressive disease of the nervous system affecting movement and cognitive function. … Continue Reading Study first to link immunogenetics to non-familial Parkinson’s disease.
An estimated 100,000 Canadians live with multiple sclerosis; there is currently no cure for the disease. Modern scientific understanding has considered multiple sclerosis (MS) to be a disease controlled by the … Continue Reading Specific subset of b-cell responsible for Multiple Sclerosis disease activity identified.
The need for a new approach to treat Alzheimer’s is an urgent priority for governments across the globe. It is the most common age-related dementia, and the number of people … Continue Reading Gamechanging human study identifies 3 distinct subtypes of Alzheimer’s disease.