Microglia-based mechanism that reduces effect of cocaine on the brain identified.
It is known that repeated cocaine-use results in the development of behavioural sensitization, accompanied by a decrease in excitatory synaptic strength in the nucleus accumbens (NAc). Furthermore, glial cells in the NAc are activated by drugs of abuse, however, the contribution of glia to the development of addictive behaviours is unknown. Now, a study from researchers at McGill University shows
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