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Sperm carries information about dad’s weight – healthinnovations

This visual abstract shows how spermatozoa from obese men carry a distinct epigenetic signature compared to lean men, in particular at genes controlling brain development and function. The sperm methylome is dynamically remodeled after gastric-bypass-induced weight loss, notably at gene regions implicated in the central control of appetite. Credit: Donkin and Versteyhe et al./Cell Metabolism 2015.

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