It is known that the age-related growth differentiation factor 11 (GDF11) is member of the transforming growth factor β superfamily of proteins. Circulating GDF11 concentrations appear to decline with age, and its depletion is associated with cardiac hypertrophy and other morbidities. Knowledge of GDF11 regulation is limited, however, and the effects of natural genetic variation on GDF11 levels are currently undefined.  Now, a study from … Continue reading Study identifies previously unknown molecular pathway in aging.