Rheumatoid arthritis (RA) is the most common inflammatory of the types of arthritis affecting around 1% of the population. RA is an autoimmune disease that causes inflammation, pain, stiffness and … Continue Reading Gene regulating severity of tissue damage in rheumatoid arthritis identified.
Inflammatory bowel disease (IBD) is a painful, chronic inflammation of the gastrointestinal tract, affecting roughly two million children and adults in the U.S. Inflammatory bowel disease (IBD) beginning in childhood tends … Continue Reading Study identifies gene variants in inflammatory bowel disease under Age 5.
First comprehensive study of genetic risks for Inflammatory Bowel Disease (IBD) in African-Americans performed.
Crohn’s disease and ulcerative colitis are chronic autoimmune diseases that affect as many as 1.6 million Americans. Patients with Inflammatory Bowel Disease (IBD) have immune systems that attack their own … Continue Reading First comprehensive study of genetic risks for Inflammatory Bowel Disease (IBD) in African-Americans performed.
To be activated, T cells must first recognize an antigen, receive appropriate costimulatory signals, and then encounter inflammatory cytokines to expand the immune response. This immune response has been harnessed … Continue Reading New T-cell regulation discovery set to rewrite immunology text books.
Autoimmune uveitis, which accounts for up to 15% of severe visual handicap in the Western world, affects the working-age population and significantly affects public health. Patients often have detectable immune … Continue Reading Study reveals how T-cells traverse blood-retinal barrier in eye disease.
The immune system not only responds to infections and other potentially problematic abnormalities in the body, it also contains a built-in brake in the form of regulatory T cells. These … Continue Reading Researchers identify a previously unknown regulator of the immune system.
To combat pathogens, the immune system has developed various mechanisms to detect, defend against and even destroy micro-organisms that are harmful to the body. This includes antimicrobial peptides and natural … Continue Reading International team identifies bacteria which protect against type 1 diabetes.
It’s been known that in the presence of obesity, the endoplasmic reticulum (ER) dysfunction is unable to perform one of its key functions: initiating a cascade of intracellular events called … Continue Reading New obesity-related mechanism identified in the development of Type 2 diabetes.
Type 1 diabetes is an autoimmune disease, which primarily surfaces in childhood, where the immune system attacks the insulin-producing cells of the pancreas, leaving children facing a lifetime of daily … Continue Reading Lower levels of four proteins crucial for immune response found in T1 diabetes patients.
It is well-known that insulin resistance is common in people who are obese, pre-diabetic or have Type 2 diabetes. The fact that obesity increases the risk of cardiovascular disease and … Continue Reading Researchers image the effect of insulin resistance in the brain, link to Alzheimer’s disease.
Impaired activation of mitochondrial energy metabolism in the presence of glucose has been demonstrated in pancreatic beta-cells from patients with type 2 diabetes. The cause of this dysfunction has been … Continue Reading New diagnostic identifies mitochondria dysfunction in Type 2 diabetes.
There is currently great interest in treating ulcerative colitis with fecal microbiota transplantation (FMT), which involves transplanting gut fecal bacteria from healthy people into patients with ulcerative colitis. Now, two new … Continue Reading First ever trial of fecal microbiota transplantation in humans with ulcerative colitis successful.
Involuntary childlessness is common, and in half of all cases attributable to infertility in the man. Although male infertility has many possible causes, it often remains unexplained. Now, a new … Continue Reading Researchers identify new cause of male infertility in human studies.
Metabolism experts are increasingly convinced that obesity and many of the pathogenic changes it entails, such as Metabolic Syndrome and type 2 diabetes, are a result of chronic inflammatory processes … Continue Reading Researchers identify enzyme in animal model responsible for metabolism disorders due to obesity.
An innocent mistake made by a graduate student in a Northwestern Medicine lab (they accidentally used male mice instead of female mice during an experiment) has led scientists to an … Continue Reading Simple mistake made in study leads to sex bias breakthrough in multiple sclerosis.
A drug that could halt the progression of multiple sclerosis may soon be developed thanks to a discovery by a team at the CHUM Research Centre and the University of … Continue Reading New treatment blocks progression of mutliple sclerosis in animal model.