The female biological clock is constantly ticking down with the quality of a woman’s eggs directly related to her ability to have a baby and her level of fertility. A … Continue Reading Researchers reverse the reproductive clock in mice.
Telomeres are our own personal inbuilt clock found at the end of chromosomes dictating how and when we age, with these protective caps ensuring no damage comes to the DNA … Continue Reading Researchers identify previously unknown telomere-specific protein.
Epigenetic dysfunction is implicated in many neurological and psychiatric diseases, including Alzheimer’s disease and schizophrenia. Consequently, histone deacetylases (HDACs) are being aggressively pursued as therapeutic targets. However, a fundamental knowledge … Continue Reading Researchers image the epigenetics of the human brain for the first time ever.
One of the processes associated with aging is progressive shortening of telomeres, DNA-protecting structures at the ends of chromosomes, like the plastic tips on shoelaces. Each time a cell divides, … Continue Reading Male hormone reverses cell aging, increases telomere length, in clinical trial.
Telomeres are the ends of chromosomes, which package genetic information to pass from parents to children. As the cell divides, these endcaps help keep the genetic information stable and prevent … Continue Reading New technique detects telomere length for research into cancer and aging.
Heart failure is one of the main health problems worldwide, and the urgent medical needs relating to it have positioned cardiovascular research as one of the most actively evolving fields … Continue Reading Study links adult heart regeneration to telomere length in animal model.
Telomeres are critical for maintaining genomic integrity with telomere dysfunction or shortening commonly acquired during the process of tumour development. To add to this cancer cells require a mechanism to … Continue Reading Mystery solved as protein expressed in response to telomere shortening identified.
The mammalian Y chromosome encodes a specialized set of genes that are essential for male viability and fertility. In particular, the sex-determining region Y (SRY) protein is necessary to initiate … Continue Reading Male mice without any Y chromosome produce offspring with assisted reproduction.
Telomeres are repetitive nucleotide sequences located at the termini of chromosomes. Telomere shortening in humans can induce cellular old-age, which blocks cell division. This mechanism prevents genomic instability and development … Continue Reading Researchers identify new enzyme critical to maintaining human telomere length.
Chromosomal alterations and deletions are often observed in cancers. Recurrent genetic losses are thought to contribute to disease processes through deregulating critical cellular programs that govern proliferation and differentiation. However, … Continue Reading Researchers identify precision medicine, suppressor gene for acute myeloid leukemia.
Antigen receptor genes are assembled by controlled, large-scale deletions and inversions. Errors in this process, known as V(D)J recombination, produce aberrant genomic rearrangements, which can fuel the development of T- … Continue Reading Researchers identify points where incorrect immune cell DNA editing causes blood cancer.
First comprehensive study of genetic risks for Inflammatory Bowel Disease (IBD) in African-Americans performed.
Crohn’s disease and ulcerative colitis are chronic autoimmune diseases that affect as many as 1.6 million Americans. Patients with Inflammatory Bowel Disease (IBD) have immune systems that attack their own … Continue Reading First comprehensive study of genetic risks for Inflammatory Bowel Disease (IBD) in African-Americans performed.
Last December, researchers identified more than 1,000 gene mutations in individuals with autism, however, it was still unclear as to how these mutations increased the risk for autism. Now, UNC … Continue Reading Researchers identify the single epigenetic mutation which causes autism.
Studying telomeres, the structures that protect the ends of chromosomes, has become a key issue in biology. In recent years, not only has their relation to aging been confirmed; defective … Continue Reading Extensive review maps all known diseases caused by defective telomeres.
Idiopathic pulmonary fibrosis (IPF) causes a gradual loss of respiratory capacity and can be lethal within a few years. The cause is unknown, although it can be attributed to a … Continue Reading Researchers identify the causal link between telomere shortening and idiopathic pulmonary fibrosis.
In the most severe form of male infertility, men do not make any measurable levels of sperm. This condition, called azoospermia, affects approximately 1 percent of the male population and … Continue Reading Researchers identify a new gene responsible for male infertility.