Chronic kidney disease (CKD) is a major public health issue, affecting over 10 percent of the global population, frequently occurring as a result of other disorders such as hypertension, diabetes, … Continue Reading Blocking brain signals detected in the kidney could help unlock treatments for kidney failure.
Pain is an unpleasant sensory and emotional experience caused by stimulating nerve receptors contained within tissue damaged by trauma. Usually pain dissipates once the traumatic stimulus is removed and the … Continue Reading Study claims to have found the center of pain in the brain.
Chronic pain is defined as any persistent pain which lasts more than 3 months, with research indicting over 85% of patients suffering from chronic pain are affected by severe depression, … Continue Reading Molecular link between chronic pain and depression identified.
An out-of-control pandemic still growing after many decades, chronic pain is the most common reason for physician consultation in most developed countries around the world, with almost one in five … Continue Reading Previously unknown sensory organ identified.
Approximately half the adult population in the United States is suffering from back or neck pain whose treatment and care costs result in an estimated 195 billion USD a year. … Continue Reading Spinal discs made of engineered living tissue implanted in large animal model.
Pain hypersensitivity can spread to unaffected body regions immediately surrounding the initial insult. Sometimes it can even spread to the opposite site of the body or to large body areas … Continue Reading Pain-initiating function of glial cells identified for the first time.
The inflammatory response is an integral part of the innate immune mechanism that is triggered in response to a real or perceived threat to tissue homeostasis, with a primary aim … Continue Reading New class of molecule identified in central role of inflammation and the immune system.
Patients suffering from so-called immune-mediated neuropathies frequently have a long medical record. As there are no diagnostic tests available to reliably diagnose the disease, the diagnosis is frequently made belatedly … Continue Reading Study identifies previously unknown cause of immune neuropathy.
Neuropathic pain is deﬁned as pain initiated or caused by a primary lesion or dysfunction in the nervous system. Chronic neuropathic leg pain is the most common form of neuropathic … Continue Reading Neuroimaging shows that spinal cord stimulation reduces emotional aspect of chronic pain.
It is known that chronic inflammation in the gut increases the risk of colon cancer by as much as 500%. Therefore, the genetic basis and mechanism of cancer proliferation in … Continue Reading Researchers show how gut inflammation initiates colon cancer.
Chronic kidney disease causes approximately 47,000 deaths a year and is known as a silent killer, due to the fact most people don’t realize they have it until the disease … Continue Reading Early warning blood-marker identified for chronic kidney disease.
In the treatment of pain, a common course is to treat patients with opioid medications, these medications show limited effectiveness for neuropathic pain and come with safety and addiction issues. … Continue Reading Researchers map how antidepressants lessen neuropathic pain.
Normal kidney function is crucial for regulation of total blood volume and vascular tone. Chronic kidney disease is the reduced ability of the kidney to carry out these functions in … Continue Reading Human study shows kidney impairment boosts risk of stroke and dementia.
Chronic spinal cord injury (SCI) is a formidable hurdle that prevents a large number of injured axons from crossing the lesion, particularly the corticospinal tract (CST). Patients inflicted with SCI … Continue Reading Researchers identify precision medicine to regenerate corticospinal tract axons.
Diabetic neuropathy is a condition in which perpetually high blood sugar causes nerve damage, resulting in a myriad of symptoms such as numbness, reduced ability to detect painful stimuli, muscle … Continue Reading Stem cell injections improve diabetic neuropathy in animal models.
The results of a study presented today at the European League Against Rheumatism Annual Congress revealed that DNA methylation, a mechanism that regulates gene expression, could influence the progression of … Continue Reading First ever study maps the epigenetics of AS development caused by environmental factors.