In the female reproductive system ovarian follicles are the basic unit of the ovary, consisting of an immature egg, known as an oocyte, surrounded by granulosa cells. Besides being crucial … Continue Reading Mice born from eggs derived from the granulosa cells surrounding oocytes.
Red blood cells are the most abundant cells in the human body, and transport oxygen and carbon dioxide. Millions of people worldwide suffer from anaemia, a condition in which the … Continue Reading Study identifies the genetic code of red blood cells.
Mesenchymal stem cells (MSCs) are among the major stem cells used for cell therapy and regenerative medicine. In-vivo cell-tracking by magnetic resonance imaging (MRI) is crucial for regenerative medicine, allowing … Continue Reading Biomimetic method produces large numbers of MRI-trackable mesenchymal stem cells.
Unprecedented precision study identifies the four genes responsible for blood stem cell development.
Every day, over 100 billion new mature blood cells are generated in an adult human. This major production places high demands on the blood stem cells which must be capable … Continue Reading Unprecedented precision study identifies the four genes responsible for blood stem cell development.
Infertility affects up to 15% of couples, with roughly one-third of all cases being caused by male infertility. One major cause of male infertility is the failure of precursor germ … Continue Reading Stem cell technique makes first ever viable sperm-in-a-dish.
It is known that the age-related growth differentiation factor 11 (GDF11) is member of the transforming growth factor β superfamily of proteins. Circulating GDF11 concentrations appear to decline with age, … Continue Reading Study identifies previously unknown molecular pathway in aging.
Due in part to improvements in screening, the rates of new colorectal cancer diagnoses have been falling in the United States for people ages 50 and older. However, for people … Continue Reading Study identifies different genetic drivers of colorectal cancer in older and younger patients.
Kidney failure is a growing problem in the United States, every year, approximately 10,000 kidneys become available for transplant into patients with end-stage kidney disease. However, the waiting lists for … Continue Reading Mammalian kidney identified as a ‘blood-generating’ organ for the first time.
A leading cause of cancer deaths worldwide, colon cancer is famously resistant to treatment. One reason for this is a group of persisting cancer cells in the colon that cause … Continue Reading Researchers use vitamin A to prevent relapsing colon cancer.
In the field of iPS cell-based regenerative medicine, advanced research with clinical applications for many organs and tissues, such as the retina, has steadily progressed. However, growing a kidney from … Continue Reading Human stem cell-derived kidneys connect to blood vessels when transplanted into mice.
Aging is a major risk factor for many human diseases, and in vitro generation of human neurons is an attractive approach for modeling aging-related brain disorders. While aggressive familial early … Continue Reading New technique enables researchers to grow old human brain cells for the first time.
Chromosomal alterations and deletions are often observed in cancers. Recurrent genetic losses are thought to contribute to disease processes through deregulating critical cellular programs that govern proliferation and differentiation. However, … Continue Reading Researchers identify precision medicine, suppressor gene for acute myeloid leukemia.
Free radicals are especially reactive atoms or groups of atoms that have one or more unpaired electrons. They are produced in the body as a by-product of normal metabolism and … Continue Reading New findings on the free radical theory of aging and mitochondrial damage.
Researchers at the University of Illinois have identified a molecular mechanism that directs embryonic stem cells to mature into endothelial cells, the specialized cells that form blood vessels. Understanding the … Continue Reading Researchers begin to map the epigenetics that turn stem cells into blood vessel cells.
Stem cells, which have the potential to turn into any kind of cell, offer the tantalizing possibility of generating new tissues for organ replacements, stroke victims and patients of many … Continue Reading Researchers have discovered a new pathway in stem cell differentiation.
Newborn neurons generated from neural progenitor cells in a brain region called the hippocampus play an important role in learning and memory in adults. However, the molecular mechanisms that control … Continue Reading Researchers map epigenetic pathway of neurogenesis in the hippocampus.