A once primordial parasite, mitochondria are now crucial organelles in cells responsible for producing more than 90% of the energy needed by the body to sustain life and support organ … Continue Reading Proof-of-concept for synthetic enzyme to treat all mitochondrial disorders.
In the course of evolution, nature has produced thousands of enzymes to facilitate the myriad of chemical reactions taking place inside living organisms every day. Enzymes are responsible for accelerating … Continue Reading Researchers develop an artificial enzyme that speeds reactions in living cells.
Nanomachines made from synthetic DNA motors have the potential to mimic natural protein motors in cells, however, the operation of synthetic DNA motors in living corpuscles has not yet been … Continue Reading Autonomous nanomachines perform biologic functions in live cells.
The onset of ALS, also known as Lou Gehrig’s disease, is marked by the gradual degradation and eventual death of neuronal axons, the slender projections on nerve cells which transmit … Continue Reading Researchers identify the key instigator of neuron damage in sporadic and inherited ALS.
For decades, scientists have known that people with two copies of a gene called apolipoprotein E4, or ApoE4, are much more likely to have Alzheimer’s disease at age 65 than … Continue Reading Study shows why people with the ApoE4 gene are more susceptible to Alzheimer’s disease.
African sleeping sickness is caused by the single-cell parasite Trypanosoma brucei and is spread by infected tsetse flies in sub-Saharan Africa. The disease is deadly, affecting both humans and livestock … Continue Reading Previously unknown protective enzyme identified in the sleeping sickness parasite.
Telomeres are critical for maintaining genomic integrity with telomere dysfunction or shortening commonly acquired during the process of tumour development. To add to this cancer cells require a mechanism to … Continue Reading Mystery solved as protein expressed in response to telomere shortening identified.
The human heart is a remarkable muscle, beating more than 2 billion times over the average life span. However, the heart’s efficiency can decrease over time. One major contributor to … Continue Reading Study identifies protein with power to improve heart function.
Spinal muscular atrophy is a debilitating disease that causes weakness and wasting of the muscles. The disease ranges in severity with patients experiencing different symptoms, from the inability to sit … Continue Reading Molecular mechanism underlying neurodegeneration in spinal muscular atrophy identified.
Being able to detect early on whether a cancer therapy is working proffers obvious benefits for therapy-outcomes whilst influencing the course of treatment and improving the quality of life for … Continue Reading Novel ‘reporter’ nanoparticle reveals cancer treatment effectiveness in real-time.
Mitochondria are spherical or rod-shaped organelles found within the cytoplasm of eukaryotic cells, referred to as the powerhouse of the cell as they act as the site for the production … Continue Reading Decades-long mystery solved of how mitochondria’s energy currency is maintained.
More than 40,000 babies in the United States, or about 1 in 100 births, are born annually with a congenital heart defect. Congenital heart defect, is a problem in the … Continue Reading Researchers identify natural triggers to ‘override’ congenital heart defect in newborns.
Epigenetics is a process whereby environmental factors can affect DNA and the mechanism by which DNA is transcribed and translated into proteins. Epigenetic regulation has been observed to affect a … Continue Reading Researchers reprogram social behaviour in carpenter ants using epigenetic drugs.
As a part of the human immune system, white blood cells create a number of enzymes that help fight disease. Sometimes, these enzymes can malfunction, causing damage to the body … Continue Reading Study sheds light on cancer-spreading enzymes produced by the immune-system.
Telomeres are repetitive nucleotide sequences located at the termini of chromosomes. Telomere shortening in humans can induce cellular old-age, which blocks cell division. This mechanism prevents genomic instability and development … Continue Reading Researchers identify new enzyme critical to maintaining human telomere length.
An enzyme called telomerase plays a significant role in aging and most cancers. Telomerase’s primary job is to maintain the DNA in telomeres, the structures at the ends of a … Continue Reading Study provides previously unseen structure of telomere-controlling enzyme.