Approximately 16% of adults in the United States report drug use, however, not everyone who experiments with drugs becomes an addict. Environmental and societal factors play a role in addiction … Continue Reading First ever study identifies epigenetic markers that influence addiction in animal model.
In the brain, patterns of neural activity are perfectly balanced. The interplay between activating and inhibitory neurotransmitters ensures that the level of activity stays within the physiological range. Neuronal degeneration … Continue Reading Researchers begin to map neuroprotective pathway after epileptic seizure.
It is known that the age-related growth differentiation factor 11 (GDF11) is member of the transforming growth factor β superfamily of proteins. Circulating GDF11 concentrations appear to decline with age, … Continue Reading Study identifies previously unknown molecular pathway in aging.
It has long been known that transcriptional regulation during embryonic development relies on the regulation of thousands of genes. Within a particular cell type defined sets of DNA-binding transcription factors … Continue Reading Researchers map how transcription factors interact to create a heart.
The human nervous system is made up of an astonishing diversity of neurons. And yet only a very small number of proteins are needed to generate and determine the identity … Continue Reading Researchers identify a previously unknown regulatory mechanism of neurogenesis.
Major depressive disorder is a highly familial illness and the leading cause of disability worldwide for persons 15 to 44 years of age. It is associated with increased mortality resulting … Continue Reading Study shows that both genetics and environment impact depression.
Epigenetics is a process whereby environmental factors can affect DNA and the mechanism by which DNA is transcribed and translated into proteins. Epigenetic regulation has been observed to affect a … Continue Reading Researchers reprogram social behaviour in carpenter ants using epigenetic drugs.
A fundamental law of genetics states that progenies do not inherit epigenetically-based adaptive, pathological or neural features acquired in response to environmental conditions. However, recent studies seem to contradict this … Continue Reading Researchers map ‘epigenetic inheritability’ in fathers sperm caused by diet.
The epidermal growth factor receptor (EGFR) is a potent tyrosine kinase, which regulates basic cell functions such as proliferation. EGFR has been strongly associated with poor prognosis in many types … Continue Reading Researchers identify a previously unknown mechanism in cancer metastasis.
As humans grow older, they lose strength and muscle mass. Skeletal muscle weakness and atrophy are among the most pervasive and disruptive effects of aging. In nearly all people, even … Continue Reading Researchers identify precise cause of muscle weakness and loss due to aging.
Researchers have believed for a long time that cancerous stem cells may trigger reproduction and growth of cells within a cancer. These cancerous stem cells lurking within the cancer, under … Continue Reading New research supports theory that cancer is a ‘stem-cell disease’.
The immune system not only responds to infections and other potentially problematic abnormalities in the body, it also contains a built-in brake in the form of regulatory T cells. These … Continue Reading Researchers identify a previously unknown regulator of the immune system.
After a hit to the head or rapid whiplash, whether from a car crash, athletic event or other accident, millions of Americans develop traumatic brain injuries (TBIs) each year. TBIs … Continue Reading Large-scale human study shows blood test predicts prognosis for traumatic brain injuries.
Cancer researchers have known for years that tumours have unusual metabolisms, their rapid use of glucose is used as a diagnostic tool for tumours in PET scans. However, only recently … Continue Reading Study identifies new nutrient-based mechanism of cancer proliferation, drug resistance.
Heart regeneration a step closer as researchers identify progenitor cell exclusively for heart muscle.
Future therapies for failing hearts are likely to include stem-like cells and associated growth factors that regenerate heart muscle. Now, researchers from the University of Pennsylvania have just taken an … Continue Reading Heart regeneration a step closer as researchers identify progenitor cell exclusively for heart muscle.
A new collaborative study led by researchers at Sanford-Burnham Medical Research Institute provides new insight into the molecular changes that lead to resistance to a commonly prescribed group of drugs … Continue Reading Researchers identify new epigenetic pathway in drug-resistant melanoma.