When a person catches a bacterial infection, they are usually prescribed a course of antibiotics, medicines used to prevent and treat illnesses caused by this class of pathogens. Antibiotic resistance … Continue Reading New bacterial survival mechanism identified in antibiotic resistance.
Cystic fibrosis is a genetic-based disorder primarily affecting the lungs. The gene affected by cystic fibrosis is CFTR (cystic fibrosis transmembrane conductance regulator), controlling the movement of electrolytes in and … Continue Reading New lung cell type discovered.
Idiopathic pulmonary fibrosis is a potentially lethal disease associated with the presence of critically short telomeres, and currently lacking effective treatment. Now, a study from researchers at CNIO cures this … Continue Reading Researchers cure lung fibrosis in mice by lengthening telomeres.
It is known that patients with Crohn’s disease have uncontrolled inflammation in their gut, which can lead to intestinal fibrosis and narrowing that can slow or block the movement of … Continue Reading Study identifies immune cells critical for the development of fibrosis in Crohn’s disease.
More than 600,000 patients in the United States alone suffer from end-stage liver disease, or cirrhosis. The only available cure is liver transplantation, but the shortage of donor livers means … Continue Reading New approach repairs living liver from within with no need of cell transplants.
Due to the recent episodes of severe air pollution in eastern Asia, there is growing concern about the systemic effects of air pollution on human health. Along with the other … Continue Reading Researchers identify mechanism for air pollution-induced liver disease.
Studying telomeres, the structures that protect the ends of chromosomes, has become a key issue in biology. In recent years, not only has their relation to aging been confirmed; defective … Continue Reading Extensive review maps all known diseases caused by defective telomeres.
Idiopathic pulmonary fibrosis (IPF) causes a gradual loss of respiratory capacity and can be lethal within a few years. The cause is unknown, although it can be attributed to a … Continue Reading Researchers identify the causal link between telomere shortening and idiopathic pulmonary fibrosis.
Nearly 70,000 people worldwide are living with cystic fibrosis, a life-threatening genetic disease. There currently is no cure for the condition, however, researchers from the University of Missouri have identified … Continue Reading Previously unseen mechanism and component in protein that causes cystic fibrosis identified.
Lung diseases like emphysema and pulmonary fibrosis are common among people with malfunctioning telomeres, the ‘caps’ or ends of chromosomes. Now, researchers from Johns Hopkins University say they have discovered … Continue Reading Premature aging of stem cell telomeres, not inflammation, linked to emphysema.
By uncovering the mechanism by which fibrous tissue cells in the lung multiply, researchers at The Children’s Hospital Los Angeles (CHLA), Keck School of Medicine, Nanjing Drum Tower Hospital, Instituto Nacional de … Continue Reading Researchers map and control pulmonary fibrosis signalling pathway in preclinical trials.
A new method of testing the most common cause of life-threatening infection in people with cystic fibrosis could improve efforts to study and combat the illness. The bacterium Pseudomonas aeruginosa … Continue Reading Researchers develop first human model of P. aeruginosa infection in cystic fibrosis lungs.
A team led by UC San Francisco has discovered why mucus in the lungs of people with cystic fibrosis (CF) is thick, sticky and difficult to cough up, leaving these … Continue Reading Researchers identify the mechanism cystic fibrosis uses to thicken mucus in the lungs.
Mutation of one gene is all it takes to get cystic fibrosis (CF), but disease severity depends on many other genes and proteins. For the first time, researchers at the … Continue Reading Researchers map epigenetic pathways linked to cystic fibrosis disease severity.
Mutations in a gene that helps repair damaged chromosome ends may make smokers, especially female smokers, more susceptible to emphysema, according to results of a new study led by Johns … Continue Reading Epigenetic mutation which shortens telomeres linked to greater emphysema risk in smokers.
Researchers from Brigham and Women’s Hospital (BWH) have identified what they believe to be the cells responsible for fibrosis, the buildup of scar tissue. Fibrotic diseases, such as chronic kidney … Continue Reading Researchers have identified the cells responsible for fibrosis, the buildup of scar tissue.