Crohn’s disease, a common inflammatory disorder of the intestinal tract, can have devastating consequences for a patient’s quality of life. Although people with the disease are typically treated with powerful … Continue Reading Researchers identify 2 distinct genetic subtypes in Crohn’s disease patients.
Living organisms experience various stresses during their lifespans. These stresses include radiation, ultraviolet rays, and chemical substances which directly damage DNA and cause cancer. Organisms are able to speedily repair … Continue Reading Study identifies genes which control cellular senescence.
Melanoma is one of the types of cancer that poses the greatest challenge to researchers because it manifests itself in many ways, it contains a large number of mutations and … Continue Reading Researchers identify a new molecular biomarker for malignant melanoma.
It is known that patients with Crohn’s disease have uncontrolled inflammation in their gut, which can lead to intestinal fibrosis and narrowing that can slow or block the movement of … Continue Reading Study identifies immune cells critical for the development of fibrosis in Crohn’s disease.
The children of traumatized people have long been known to be at increased risk for post-traumatic stress disorder (PTSD). However, there are very few opportunities to examine biologic alterations in … Continue Reading Trauma’s inherited epigenetic fingerprint observed in children of Holocaust survivors.
For decades, scientists have known that people with two copies of a gene called apolipoprotein E4, or ApoE4, are much more likely to have Alzheimer’s disease at age 65 than … Continue Reading Study shows why people with the ApoE4 gene are more susceptible to Alzheimer’s disease.
Epigenetic dysfunction is implicated in many neurological and psychiatric diseases, including Alzheimer’s disease and schizophrenia. Consequently, histone deacetylases (HDACs) are being aggressively pursued as therapeutic targets. However, a fundamental knowledge … Continue Reading Researchers image the epigenetics of the human brain for the first time ever.
Like a magician, the freshwater flatworm known as planaria can survive decapitation or even being cut into many pieces. Its ability to fully regenerate from tiny remnants of tissue is … Continue Reading Elusive key molecular signal for planarian stem cell regeneration identified.
High-density lipoproteins are complex particles composed of multiple proteins which transport fat molecules around the body. High-density lipoprotein particles are sometimes referred to as good cholesterol because they can transport … Continue Reading Human study identifies link between the GALNT2 gene and levels of HDL cholesterol.
Congenital long QT syndrome (LQTS), affecting approximately 1 in 2000 people, is a heritable cardiac disease where patients are at an increased risk for LQTS-triggered seizures, and sudden cardiac arrest … Continue Reading Researchers identify genetic link between a rare heart disorder and an increased risk of seizures.
It is known that skeletal muscle regeneration is impaired in age-related diseases such as sarcopenia, which is marked by reduced muscle regenerative capacity with aging, due in part to a … Continue Reading Study identifies gene responsible for regeneration of injured muscle by adult stem cells.
It is known that the formation of large numbers of polyps in the colon has a high probability of developing into colon cancer, if left untreated. The large-scale appearance of … Continue Reading Previously unknown gene mutation in hereditary colon cancer identified.
Colorectal cancer is the development of cancer from the colon or rectum, due to the abnormal growth of cells that have the ability to invade or spread to other parts … Continue Reading Genetic cause of 15% of all colorectal cancer diagnoses identified.
Leukemia, or blood cancer, involves pathological alterations in the body’s hematopoietic system. In acute myeloid leukemia, it is specifically the bone marrow that is affected. In a healthy body, different … Continue Reading Previously unknown cell-death pathway mapped in leukemia cells.
Charcot-Marie-Tooth Disease (CMT) is a family of inherited disorders of the peripheral nervous system, affecting approximately one in 2,500 Americans. Its most common iteration, CMT1, comes in many forms, most … Continue Reading Researchers identify previously unknown genetic cause of inherited neuropathy.
Obesity is a global health problem that poses a major risk factor for life-threatening diseases such as cardiovascular disease, cancer, and neurodegeneration. Recent studies have identified specific loci associated with … Continue Reading Study maps a molecular link between insulin-sensitivity and obesity.