Critically, the growth of children’s bones depends on growth plates situated close to the end of all long bones in the body. These plates are narrow discs of cartilage providing … Continue Reading New mechanism of bone growth uncovered.
Angiogenesis, the growth of new blood vessels from pre-existing ones, is required for wound healing, menstruation, embryogenesis and various pathological conditions including tumour growth. Macrophages, key cells of the innate … Continue Reading Immune cells shown to facilitate tumour growth by forming primitive vascular channels.
When the nervous system is developing neurons send their axons, the parts of neurons that make up the body’s nerves, to make connections with other neurons. For instance, a neuron in … Continue Reading Researchers identify protein complex that helps direct growth of axons.
Memories are formed at structures in the brain known as dendritic spines which communicate with other brain cells via synapses. It is known that the number of these brain connections … Continue Reading Study identifies cause of dendritic pruning defect linked to autism and schizophrenia.
Adult stem cells provide the body with a reservoir from which damaged or used up tissues can be replenished. In organs like the intestines and skin, which need constant rejuvenating, … Continue Reading Study verifies how stem cells get activated to produce new hair.
It is known that the age-related growth differentiation factor 11 (GDF11) is member of the transforming growth factor β superfamily of proteins. Circulating GDF11 concentrations appear to decline with age, … Continue Reading Study identifies previously unknown molecular pathway in aging.
The epidermal growth factor receptor (EGFR) is a potent tyrosine kinase, which regulates basic cell functions such as proliferation. EGFR has been strongly associated with poor prognosis in many types … Continue Reading Researchers identify a previously unknown mechanism in cancer metastasis.
Everyone occasionally feels blue or sad. However, these feelings are usually short-lived and pass within a couple of days. When a person has depression, it interferes with daily life. Depression … Continue Reading Study identifies new diagnostic brain protein in depression.
Researchers have believed for a long time that cancerous stem cells may trigger reproduction and growth of cells within a cancer. These cancerous stem cells lurking within the cancer, under … Continue Reading New research supports theory that cancer is a ‘stem-cell disease’.
Cancer researchers have known for years that tumours have unusual metabolisms, their rapid use of glucose is used as a diagnostic tool for tumours in PET scans. However, only recently … Continue Reading Study identifies new nutrient-based mechanism of cancer proliferation, drug resistance.
Heart regeneration a step closer as researchers identify progenitor cell exclusively for heart muscle.
Future therapies for failing hearts are likely to include stem-like cells and associated growth factors that regenerate heart muscle. Now, researchers from the University of Pennsylvania have just taken an … Continue Reading Heart regeneration a step closer as researchers identify progenitor cell exclusively for heart muscle.
A new collaborative study led by researchers at Sanford-Burnham Medical Research Institute provides new insight into the molecular changes that lead to resistance to a commonly prescribed group of drugs … Continue Reading Researchers identify new epigenetic pathway in drug-resistant melanoma.
A protein that normally fosters tissue repair instead acts to inhibit healing when sugar levels are high, according to a study in The Journal of Cell Biology. The data findings … Continue Reading Researchers map epigenetic cause of slowed diabetic wound healing.
Researchers identify how the blood-brain barrier is maintained to control ‘tight junction’ function.
It has long been known that the brain is protected from alterations elsewhere in the body by a highly regulated gateway known as the blood-brain barrier, which allows only selected … Continue Reading Researchers identify how the blood-brain barrier is maintained to control ‘tight junction’ function.
Scientists from the Spanish National Cancer Research Center (CNIO) have discovered that the MCRS1 protein, in response to an excess of nutrients, induces an increase in the activity of mTOR … Continue Reading Researchers identify an oncogene regulated by nutrients.
Researchers at UC Davis have illuminated an important distinction between mice and humans, how human livers heal. The difference centres on a protein called PPARα, which activates liver regeneration. Normally, … Continue Reading Researchers find FGF21 boosts liver regenerative ability.