Containing a mini-ecology of its own, the human gut contains trillions of bacteria, known as the microbiota, a symbiotic entity crucial for digesting food and regulating the immune system. Gut … Continue Reading Gut microbiota that impairs normal skeletal growth identified.
A decades-long raging epidemic, obesity has been shown to increase the risk of non-alcoholic fatty liver disease (NAFLD)in at least 30% of obese children, leading to liver failure requiring a … Continue Reading Alterations in infant microbiota linked to childhood obesity and liver disease.
There has been much focus on how to prevent heart disease by regulating the secretion of very low density lipoproteins (VLDL) by the liver. These lipoproteins are known to increase … Continue Reading Study shows damage to previously unknown liver protein leads to heart disease, fatty liver.
More than 600,000 patients in the United States alone suffer from end-stage liver disease, or cirrhosis. The only available cure is liver transplantation, but the shortage of donor livers means … Continue Reading New approach repairs living liver from within with no need of cell transplants.
Obesity has become a major health threat, affecting more than half a billion people worldwide in 2014. In particular, obesity increases the risk for insulin resistance, hypertension, coronary heart disease … Continue Reading Epigenetic modification which raises obesity risk and predicts fatty liver identified.
Tails in lizards and arms in starfish show an astounding ability to regrow, however, mammals have partially lost the capacity to extensively regenerate body parts. The liver is unique among … Continue Reading Researchers use epigenetic mechanism to regenerate mammalian liver.
The liver plays a critical role in how the body metabolizes drugs and produces key proteins. This is why liver models are increasingly being developed in the lab as platforms … Continue Reading Researchers successfully 3D-print biomimetic liver tissue for drug screening.
The recent surge in obesity prevalence has been greatly influenced by food intake and diet composition. Energy from food comes in three macronutrient forms- fat, protein, and carbohydrate. Over the … Continue Reading First liver-generated hormone to work with brain to control sugar-intake identified.
Malaria infection starts when the sporozoite stage of the Plasmodium parasite is injected into the skin by a mosquito. Sporozoites are known to traverse host cells before finally invading a … Continue Reading Previously unknown interaction between malaria parasites and liver cells identified.
Due to the recent episodes of severe air pollution in eastern Asia, there is growing concern about the systemic effects of air pollution on human health. Along with the other … Continue Reading Researchers identify mechanism for air pollution-induced liver disease.
Of all the body’s major organs the liver has the highest capacity to regenerate and that’s why many liver diseases, including cirrhosis and hepatitis, can often be cured by transplanting … Continue Reading Researchers discover cells that regenerate the liver without forming tumours.
In the UK liver disease has risen sharply over the past few decades and is the third biggest cause of premature mortality, with three quarters of liver deaths due to … Continue Reading Human study identifies definitive biomarker for liver disease breath test.
Acute liver failure is a rare yet life-threatening disease for young children. It often occurs extremely rapidly, for example, when a child has a fever. Yet in around 50 percent … Continue Reading Researchers identify new gene responsible for liver disease.
Telomere dysfunction is identified as origin of liver diseases such as chronic hepatitis and cirrhosis.
Telomeres are DNA regions at the ends of chromosomes that protect the genetic data of cells, preventing mutations and alterations in the DNA that could potentially cause disease. Telomeres shorten … Continue Reading Telomere dysfunction is identified as origin of liver diseases such as chronic hepatitis and cirrhosis.
The micro RNA miR-22 has long been known for its ability to suppress cancer. However, questions remain about how it achieves this feat. For example, which molecules are regulating miR-22, … Continue Reading Researchers being to map the epigenetic pathway of miR-22 cancer suppression.
Researchers at UC Davis have illuminated an important distinction between mice and humans, how human livers heal. The difference centres on a protein called PPARα, which activates liver regeneration. Normally, … Continue Reading Researchers find FGF21 boosts liver regenerative ability.